>     1== M63632   1 Lampetra japonica rhodopsin <>[BBRC174,1125-1132'91]
------MNGT---------------------------------------EG--DNFYVPF
S-----NKTGL-ARSPYEYPQ-----YYLAEPWK--------------------------
-YSALAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAMANLFM-VLFGFTVT
MYTSMN-GYFV--FGPTMCSIEGFFATLGGEVALWSLVVLAIERYIVICKPMGNF-RFGN
THAIMGVAFTWIMALAC-AAPPLVG-W-----SRYIPEGMQCSCGPDYYTLNPNFNNESY
VVYMFVVHFLVPFVIIFFCYGRLLCTV----KEAAAA-----------------------
-------------------QQ---------------------------------------
------------------------------------------------------------
-------------------ESASTQK------AEKEVTRMVVLMVIGFLVCWVPYASVAF
YIFT-HQGSD--FGATFMTLPAFFAKSSALYNPVIYILMNKQFRNCMITTL-----CCG-
--KNPLGDDE--SGASTSKTEVSSVS-T-SPVSPA-------------------------
------------------------------------------------------------
---------
>     2== U22180   1 rat opsin <rod>[J.Mol.Neurosci.5(3),207-209'94]
------MNGT---------------------------------------EG--PNFYVPF
S-----NITGV-VRSPFEQPQ-----YYLAEPWQ--------------------------
-FSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFM-VFGGFTTT
LYTSLH-GYFV--FGPTGCNLEGFFATLGGEIGLWSLVVLAIERYVVVCKPMSNF-RFGE
NHAIMGVAFTWVMALAC-AAPPLVG-W-----SRYIPEGMQCSCGIDYYTLKPEVNNESF
VIYMFVVHFTIPMIVIFFCYGQLVFTV----KEAAAQ-----------------------
-------------------QQ---------------------------------------
------------------------------------------------------------
-------------------ESATTQK------AEKEVTRMVIIMVIFFLICWLPYASVAM
YIFT-HQGSN--FGPIFMTLPAFFAKTASIYNPIIYIMMNKQFRNCMLTSL-----CCG-
--KNPLGDDE--ASATASKTE------T-SQVAPA-------------------------
------------------------------------------------------------
---------
>     3== M92038   1 chicken green sensitive cone opsin <retina>[PNAS89,5932-5936'9
------MNGT---------------------------------------EG--INFYVPM
S-----NKTGV-VRSPFEYPQ-----YYLAEPWK--------------------------
-YRLVCCYIFFLISTGLPINLLTLLVTFKHKKLRQPLNYILVNLAVADLFM-ACFGFTVT
FYTAWN-GYFV--FGPVGCAVEGFFATLGGQVALWSLVVLAIERYIVVCKPMGNF-RFSA
THAMMGIAFTWVMAFSC-AAPPLFG-W-----SRYMPEGMQCSCGPDYYTHNPDYHNESY
VLYMFVIHFIIPVVVIFFSYGRLICKV----REAAAQ-----------------------
-------------------QQ---------------------------------------
------------------------------------------------------------
-------------------ESATTQK------AEKEVTRMVILMVLGFMLAWTPYAVVAF
WIFT-NKGAD--FTATLMAVPAFFSKSSSLYNPIIYVLMNKQFRNCMITTI-----CCG-
--KNPFGDEDVSSTVSQSKTEVSSVS-S-SQVSPA-------------------------
------------------------------------------------------------
---------
>     4=p A45229 opsin, green-sensitive (clone GFgr-1) - goldfish
------MNGT---------------------------------------EG--KNFYVPM
S-----NRTGL-VRSPFEYPQ-----YYLAEPWQ--------------------------
-FKILALYLFFLMSMGLPINGLTLVVTAQHKKLRQPLNFILVNLAVAGTIM-VCFGFTVT
FYTAIN-GYFV--LGPTGCAVEGFMATLGGEVALWSLVVLAIERYIVVCKPMGSF-KFSS
SHAFAGIAFTWVMALAC-AAPPLFG-W-----SRYIPEGMQCSCGPDYYTLNPDYNNESY
VIYMFVCHFILPVAVIFFTYGRLVCTV----KAAAAQ-----------------------
-------------------QQ---------------------------------------
------------------------------------------------------------
-------------------DSASTQK------AEREVTKMVILMVFGFLIAWTPYATVAA
WIFF-NKGAD--FSAKFMAIPAFFSKSSALYNPVIYVLLNKQFRNCMLTTI-----FCG-
--KNPLGDDE-SSTVSTSKTEVSSVS-P-A------------------------------
------------------------------------------------------------
---------
>     5=p B45229 opsin, green-sensitive (clone GFgr-2) - goldfish
------MNGT---------------------------------------EG--NNFYVPL
S-----NRTGL-VRSPFEYPQ-----YYLAEPWQ--------------------------
-FKLLAVYMFFLICLGLPINGLTLICTAQHKKLRQPLNFILVNLAVAGAIM-VCFGFTVT
FYTAIN-GYFA--LGPTGCAVEGFMATLGGEVALWSLVVLAIERYIVVCKPMGSF-KFSS
THASAGIAFTWVMAMAC-AAPPLVG-W-----SRYIPEGIQCSCGPDYYTLNPEYNNESY
VLYMFICHFILPVTIIFFTYGRLVCTV----KAAAAQ-----------------------
-------------------QQ---------------------------------------
------------------------------------------------------------
-------------------DSASTQK------AEREVTKMVILMVLGFLVAWTPYATVAA
WIFF-NKGAA--FSAQFMAIPAFFSKTSALYNPVIYVLLNKQFRSCMLTTL-----FCG-
--KNPLGDEE-SSTVSTSKTEVSSVS-P-A------------------------------
------------------------------------------------------------
---------
>     6== L11864   1 Carassius auratus blue cone opsin <retina>[Biochemistry32,208-
------MKQV---------------------------------------PEFHEDFYIPI
PL----DINNLSAYSPFLVPQ-----DHLGNQGI--------------------------
-FMAMSVFMFFIFIGGASINILTILCTIQFKKLRSHLNYILVNLSIANLFV-AIFGSPLS
FYSFFN-RYFI--FGATACKIEGFLATLGGMVGLWSLAVVAFERWLVICKPLGNF-TFKT
PHAIAGCILPWISALAA-SLPPLFG-W-----SRYIPEGLQCSCGPDWYTTNNKYNNESY
VMFLFCFCFAVPFGTIVFCYGQLLITL----KLAAKA-----------------------
-------------------QA---------------------------------------
------------------------------------------------------------
-------------------DSASTQK------AEREVTKMVVVMVLGFLVCWAPYASFSL
WIVS-HRGEE--FDLRMATIPSCLSKASTVYNPVIYVLMNKQFRSCMMKMV------CG-
--KN-IEEDE--ASTSSQVTQVSSVA-P-EK-----------------------------
------------------------------------------------------------
---------
>     7== M13299   1 human BCP <>[Science232(4747),193-202'86]
------MRKM---------------------------------------SE--EEFYL-F
K-----NISSV---GPWDGPQ-----YHIAPVWA--------------------------
-FYLQAAFMGTVFLIGFPLNAMVLVATLRYKKLRQPLNYILVNVSFGGFLL-CIFSVFPV
FVASCN-GYFV--FGRHVCALEGFLGTVAGLVTGWSLAFLAFERYIVICKPFGNF-RFSS
KHALTVVLATWTIGIGV-SIPPFFG-W-----SRFIPEGLQCSCGPDWYTVGTKYRSESY
TWFLFIFCFIVPLSLICFSYTQLLRAL----KAVAAQ-----------------------
-------------------QQ---------------------------------------
------------------------------------------------------------
-------------------ESATTQK------AEREVSRMVVVMVGSFCVCYVPYAAFAM
YMVN-NRNHG--LDLRLVTIPSFFSKSACIYNPIIYCFMNKQFQACIMKMV------CG-
--KA-MTDES--DTCSSQKTEVSTVS-S-TQVGPN-------------------------
------------------------------------------------------------
---------
>     8=opsin, greensensitive  human (fragment) S07060
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------DLAE-TVIASTIS
IVNQVS-GYFV--LGHPMCVLEGYTVSLCGITGLWSLAIISWERWLVVCKPFGNV-RFDA
KLAIVGIAFSWIWAAVW-TAPPIFG-W-----SRYWPHGLKTSCGPDVFSGSSYPGVQSY
MIVLMVTCCITPLSIIVLCYLQVWLAI----RAVAKQ-----------------------
-------------------QK---------------------------------------
------------------------------------------------------------
-------------------ESESTQK------AEKEVTRMVVVMVLAFC-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------
>     9== K03494   1 human GCP <>[Science232(4747),193-202'86]
------MAQQWSLQ-R-----------------------LAGRHPQDSYEDSTQSSIFTY
T-----NSNST--RGPFEGPN-----YHIAPRWV--------------------------
-YHLTSVWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAE-TVIASTIS
VVNQVY-GYFV--LGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNV-RFDA
KLAIVGIAFSWIWAAVW-TAPPIFG-W-----SRYWPHGLKTSCGPDVFSGSSYPGVQSY
MIVLMVTCCITPLSIIVLCYLQVWLAI----RAVAKQ-----------------------
-------------------QK---------------------------------------
------------------------------------------------------------
-------------------ESESTQK------AEKEVTRMVVVMVLAFCFCWGPYAFFAC
FAAA-NPGYP--FHPLMAALPAFFAKSATIYNPVIYVFMNRQFRNCILQLF-----G---
--KK-VDDGS--ELSSASKTEVSSV----SSVSPA-------------------------
------------------------------------------------------------
---------
>    10== Z68193   1 human Red Opsin <>[]
------MAQQWSLQ-R-----------------------LAGRHPQDSYEDSTQSSIFTY
T-----NSNST--RGPFEGPN-----YHIAPRWV--------------------------
-YHLTSVWMIFVVTASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAE-TVIASTIS
IVNQVS-GYFV--LGHPMCVLEGYTVSLCGITGLWSLAIISWERWLVVCKPFGNV-RFDA
KLAIVGIAFSWIWSAVW-TAPPIFG-W-----SRYWPHGLKTSCGPDVFSGSSYPGVQSY
MIVLMVTCCIIPLAIIMLCYLQVWLAI----RAVAKQ-----------------------
-------------------QK---------------------------------------
------------------------------------------------------------
-------------------ESESTQK------AEKEVTRMVVVMIFAYCVCWGPYTFFAC
FAAA-NPGYA--FHPLMAALPAYFAKSATIYNPVIYVFMNRQFRNCILQLF-----G---
--KK-VDDGS--ELSSASKTEVSSV----SSVSPA-------------------------
------------------------------------------------------------
---------
>    11== M92036   1 Gecko gecko P521 <retina>[PNAS89,6841-6845'92]
------MTEAWNVAVF-----------------------AARRSRDD--DDTTRGSVFTY
T-----NTNNT--RGPFEGPN-----YHIAPRWV--------------------------
-YNLVSFFMIIVVIASCFTNGLVLVATAKFKKLRHPLNWILVNLAFVDLVE-TLVASTIS
VFNQIF-GYFI--LGHPLCVIEGYVVSSCGITGLWSLAIISWERWFVVCKPFGNI-KFDS
KLAIIGIVFSWVWAWGW-SAPPIFG-W-----SRYWPHGLKTSCGPDVFSGSVELGCQSF
MLTLMITCCFLPLFIIIVCYLQVWMAI----RAVAAQ-----------------------
-------------------QK---------------------------------------
------------------------------------------------------------
-------------------ESESTQK------AEREVSRMVVVMIVAFCICWGPYASFVS
FAAA-NPGYA--FHPLAAALPAYFAKSATIYNPVIYVFMNRQFRNCIMQLF-----G---
--KK-VDDGS--EASTTSRTEVSSVS-N-SSVAPA-------------------------
------------------------------------------------------------
---------
>    12== M62903   1 chicken visual pigment <>[BBRC173,1212-1217'90]
------MA-AWEAA-F-----------------------AARRRHEE--EDTTRDSVFTY
T-----NSNNT--RGPFEGPN-----YHIAPRWV--------------------------
-YNLTSVWMIFVVAASVFTNGLVLVATWKFKKLRHPLNWILVNLAVADLGE-TVIASTIS
VINQIS-GYFI--LGHPMCVVEGYTVSACGITALWSLAIISWERWFVVCKPFGNI-KFDG
KLAVAGILFSWLWSCAW-TAPPIFG-W-----SRYWPHGLKTSCGPDVFSGSSDPGVQSY
MVVLMVTCCFFPLAIIILCYLQVWLAI----RAVAAQ-----------------------
-------------------QK---------------------------------------
------------------------------------------------------------
-------------------ESESTQK------AEKEVSRMVVVMIVAYCFCWGPYTFFAC
FAAA-NPGYA--FHPLAAALPAYFAKSATIYNPIIYVFMNRQFRNCILQLF-----G---
--KK-VDDGS--EV-STSRTEVSSVS-N-SSVSPA-------------------------
------------------------------------------------------------
---------
>    13== S75720   1 chicken P-opsin <>[Science267(5203),1502-1506'95]
------MS-----------------------------------------SNSSQAP----
-------PNGT--PGPFDGPQW---PYQ-APQST--------------------------
-YVGVAVLMGTVVACASVVNGLVIVVSICYKKLRSPLNYILVNLAVADLLV-TLCGSSVS
LSNNIN-GFFV--FGRRMCELEGFMVSLTGIVGLWSLAILALERYVVVCKPLGDF-QFQR
RHAVSGCAFTWGWALLW-SAPPLLG-W-----SSYVPEGLRTSCGPNWYTGGSN--NNSY
ILSLFVTCFVLPLSLILFSYTNLLLTL----RAAAAQ-----------------------
-------------------QK---------------------------------------
------------------------------------------------------------
-------------------EADTTQR------AEREVTRMVIVMVMAFLLCWLPYSTFAL
VVAT-HKGII--IQPVLASLPSYFSKTATVYNPIIYVFMNKQFQSCLLEML-----CCGY
QPQR-TGKAS--PGTPGPHADVTAAGLR-NKVMPAHPV----------------------
------------------------------------------------------------
---------
>    14== M17718   1 D.melanogaster Rh3 <>[J.Neurosci.7,1550-1557'87]
------MESGNVSSSLFGNV------------------STALRPEARLSA----------
------ETRLLGWNVP---PEE---LRHIPEHWLTYPEPPES------------------
MNYLLGTLYIFFTLMSMLGNGLVIWVFSAAKSLRTPSNILVINLAFCDFMM--MVKTPIF
IYNSFH-QGYA--LGHLGCQIFGIIGSYTGIAAGATNAFIAYDRFNVITRPMEG--KMTH
GKAIAMIIFIYMYATPW-VVACYTETW-----GRFVPEGYLTSCTFDYLTDNFD--TRLF
VACIFFFSFVCPTTMITYYYSQIVGHVFSHEKALRDQ-----------------------
-------------------AKK-----------------------------MN-------
---VESL-----------------------------------------------------
----------------RSNVDKNKET------AEIRIAKAAITICFLFFCSWTPYGVMSL
IGAF-GDKTL--LTPGATMIPACACKMVACIDPFVYAISHPRYRMELQKRCPWL------
-----ALNEK-APESSAVASTSTTQE-P-QQTTAA-------------------------
------------------------------------------------------------
---------
>    15== X65879   1 Drosophila pseudoobscura Dpse\Rh3 <>[Genetics132(1),193-204'92
------MEYHNVSSVL-GNV------------------SSVLRPDARLSA----------
------ESRLLGWNVP---PDE---LRHIPEHWLIYPEPPES------------------
MNYLLGTLYIFFTVISMIGNGLVMWVFSAAKSLRTPSNILVINLAFCDFMM--MIKTPIF
IYNSFH-QGYA--LGHLGCQIFGVIGSYTGIAAGATNAFIAYDRYNVITRPMEG--KMTH
GKAIAMIIFIYLYATPW-VVACYTESW-----GRFVPEGYLTSCTFDYLTDNFD--TRLF
VACIFFFSFVCPTTMITYYYSQIVGHVFSHEKALRDQ-----------------------
-------------------AKK-----------------------------MN-------
---VDSL-----------------------------------------------------
----------------RSNVDKSKEA------AEIRIAKAAITICFLFFASWTPYGVMSL
IGAF-GDKTL--LTPGATMIPACTCKMVACIDPFVYAISHPRYRMELQKRCPWL------
-----AISEK-APESRAAISTSTTQE-Q-QQTTAA-------------------------
------------------------------------------------------------
---------
>    16== M17730   1 D.melanogaster Rh4 opsin <>[J.Neurosci.7,1558-1566'87]
------ME------PLCNAS------------------EPPLRPEAR-SSGN--------
-G----DLQFLGWNVP---PDQ---IQYIPEHWLTQLEPPAS------------------
MHYMLGVFYIFLFCASTVGNGMVIWIFSTSKSLRTPSNMFVLNLAVFDLIM--CLKAPIF
--NSFH-RGFAIYLGNTWCQIFASIGSYSGIGAGMTNAAIGYDRYNVITKPMNR--NMTF
TKAVIMNIIIWLYCTPW-VVLPLTQFW-----DRFVPEGYLTSCSFDYLSDNFD--TRLF
VGTIFFFSFVCPTLMILYYYSQIVGHVFSHEKALREQ-----------------------
-------------------AKK-----------------------------MN-------
---VESL-----------------------------------------------------
----------------RSNVDKSKET------AEIRIAKAAITICFLFFVSWTPYGVMSL
IGAF-GDKSL--LTQGATMIPACTCKLVACIDPFVYAISHPRYRLELQKRCPWL------
-----GVNEK-SGEISSAQST-TTQE-Q-QQTTAA-------------------------
------------------------------------------------------------
---------
>    17== X65880   1 Drosophila pseudoobscura Dpse\Rh4 <>[Genetics132(1),193-204'92
------MD------ALCNAS------------------EPPLRPEARMSSGS--------
-D----ELQFLGWNVP---PDQ---IQYIPEHWLTQLEPPAS------------------
MHYMLGVFYIFLFFASTLGNGMVIWIFSTSKSLRTPSNMFVLNLAVFDLIM--CLKAPIF
IYNSFH-RGFA--LGNTWCQIFASIGSYSGIGAGMTNAAIGYDRYNVITKPMNR--NMTF
TKAVIMNIIIWLYCTPW-VVLPLTQFW-----DRFVPEGYLTSCSFDYLSDNFD--TRLF
VGTIFLFSFVVPTLMILYYYSQIVGHVFNHEKALREQ-----------------------
-------------------AKK-----------------------------MN-------
---VESL-----------------------------------------------------
----------------RSNVDKSKET------AEIRIAKAAITICFLFFVSWTPYGVMSL
IGAF-GDKSL--LTPGATMIPACTCKLVACIEPFVYAISHPRYRMELQKRCPWL------
-----GVNEK-SGEASSAQST-TTQE-QTQQTSAA-------------------------
------------------------------------------------------------
---------
>    18== D50584   1 Hemigrapsus sanguineus opsin BcRh2 <compound eye>[J.Exp.Biol.1
------MT-------------------------------NATGPQMAYYGAASMD-FG-Y
PE----GVSIVD-FVR---PEI---KPYVHQHWYNYPPVNPM------------------
WHYLLGVIYLFLGTVSIFGNGLVIYLFNKSAALRTPANILVVNLALSDLIM-LTTNVPFF
TYNCFSGGVWM--FSPQYCEIYACLGAITGVCSIWLLCMISFDRYNIICNGFNGP-KLTT
GKAVVFALISWVIAIGC-ALPPFFG-W-----GNYILEGILDSCSYDYLTQDFN--TFSY
NIFIFVFDYFLPAAIIVFSYVFIVKAIFAHEAAMRAQ-----------------------
-------------------AKK-----------------------------MN-------
---VSTL-----------------------------------------------------
----------------R-SNEADAQR------AEIRIAKTALVNVSLWFICWTPYALISL
KGVM-GDTSG--ITPLVSTLPALLAKSCSCYNPFVYAISHPKYRLAITQHLPWF--CVH-
-----ETETK-SNDDSQSNS-TVAQD-K-A------------------------------
------------------------------------------------------------
---------
>    19== D50583   1 Hemigrapsus sanguineus opsin BcRh1 <compound eye>[J.Exp.Biol.1
------MA-------------------------------NVTGPQMAFYGSGAAT-FG-Y
PE----GMTVAD-FVP---DRV---KHMVLDHWYNYPPVNPM------------------
WHYLLGVVYLFLGVISIAGNGLVIYLYMKSQALKTPANMLIVNLALSDLIM-LTTNFPPF
CYNCFSGGRWM--FSGTYCEIYAALGAITGVCSIWTLCMISFDRYNIICNGFNGP-KLTQ
GKATFMCGLAWVISVGW-SLPPFFG-W-----GSYTLEGILDSCSYDYFTRDMN--TITY
NICIFIFDFFLPASVIVFSYVFIVKAIFAHEAAMRAQ-----------------------
-------------------AKK-----------------------------MN-------
---VTNL-----------------------------------------------------
----------------R-SNEAETQR------AEIRIAKTALVNVSLWFICWTPYAAITI
QGLL-GNAEG--ITPLLTTLPALLAKSCSCYNPFVYAISHPKFRLAITQHLPWF--CVH-
-----EKDPN-DVEENQSSN-TQTQE-K-S------------------------------
------------------------------------------------------------
---------
>    20== K02320   1 D.melanogaster opsin <>[Cell40,851-858'85]
------ME-------SFAVA------------------AAQLGPHFAPLS----------
------NGSVVD-KVT---PDM---AHLISPYWNQFPAMDPI------------------
WAKILTAYMIMIGMISWCGNGVVIYIFATTKSLRTPANLLVINLAISDFGI-MITNTPMM
GINLYF-ETWV--LGPMMCDIYAGLGSAFGCSSIWSMCMISLDRYQVIVKGMAGR-PMTI
PLALGKM---------------------------YVPEGNLTSCGIDYLERDWN--PRSY
LIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKAMREQ-----------------------
-------------------AKK-----------------------------MN-------
---VKSL-----------------------------------------------------
----------------R-SSEDAEKS------AEGKLAKVALVTITLWFMAWTPYLVINC
MGLF-KF-EG--LTPLNTIWGACFAKSAACYNPIVYGISHPKYRLALKEKCPCC--VFG-
-----KVDDG-KSSDAQSQA-TASEA-E-SKA----------------------------
------------------------------------------------------------
---------
>    21== K02315   1 D.melanogaster ninaE <>[Cell40,839-850'85]
------ME-------SFAVA------------------AAQLGPHFAPLS----------
------NGSVVD-KVT---PDM---AHLISPYWNQFPAMDPI------------------
WAKILTAYMIMIGMISWCGNGVVIYIFATTKSLRTPANLLVINLAISDFGI-MITNTPMM
GINLYF-ETWV--LGPMMCDIYAGLGSAFGCSSIWSMCMISLDRYQVIVKGMAGR-PMTI
PLALGKIAYIWFMSSIW-CLAPAFG-W-----SRYVPEGNLTSCGIDYLERDWN--PRSY
LIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKAMREQ-----------------------
-------------------AKK-----------------------------MN-------
---VKSL-----------------------------------------------------
----------------R-SSEDAEKS------AEGKLAKVALVTITLWFMAWTPYLVINC
MGLF-KF-EG--LTPLNTIWGACFAKSAACYNPIVYGISHPKYRLALKEKCPCC--VFG-
-----KVDDG-KSSDAQSQA-TASEA-E-SKA----------------------------
------------------------------------------------------------
---------
>    22== X65877   1 Drosophila pseudoobscura Dpse\ninaE <>[Genetics132(1),193-204'
------MD-------SFAAV------------------ATQLGPQFAAPS----------
------NGSVVD-KVT---PDM---AHLISPYWDQFPAMDPI------------------
WAKILTAYMIIIGMISWCGNGVVIYIFATTKSLRTPANLLVINLAISDFGI-MITNTPMM
GINLYF-ETWV--LGPMMCDIYAGLGSAFGCSSIWSMCMISLDRYQVIVKGMAGR-PMTI
PLALGKIAYIWFMSTIWCCLAPVFG-W-----SRYVPEGNLTSCGIDYLERDWN--PRSY
LIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKAMREQ-----------------------
-------------------AKK-----------------------------MN-------
---VKSL-----------------------------------------------------
----------------R-SSEDADKS------AEGKLAKVALVTISLWFMAWTPYLVINC
MGLF-KF-EG--LTPLNTIWGACFAKSAACYNPIVYGISHPKYRLALKEKCPCC--VFG-
-----KVDDG-KSSEAQSQA-TTSEA-E-SKA----------------------------
------------------------------------------------------------
---------
>    23== M12896   1 D.melanogaster Rh2 <>[Cell44,705-710'86]
------MERSHLPETPFDL--------------------AHSGPRFQAQSSG--------
------NGSVLD-NVL---PDM---AHLVNPYWSRFAPMDPM------------------
MSKILGLFTLAIMIISCCGNGVVVYIFGGTKSLRTPANLLVLNLAFSDFCM-MASQSPVM
IINFYY-ETWV--LGPLWCDIYAGCGSLFGCVSIWSMCMIAFDRYNVIVKGINGT-PMTI
KTSIMKILFIWMMAVFW-TVMPLIG-W-----SAYVPEGNLTACSIDYMTRMWN--PRSY
LITYSLFVYYTPLFLICYSYWFIIAAVAAHEKAMREQ-----------------------
-------------------AKK-----------------------------MN-------
---VKSL-----------------------------------------------------
----------------R-SSEDCDKS------AEGKLAKVALTTISLWFMAWTPYLVICY
FGLF-KI-DG--LTPLTTIWGATFAKTSAVYNPIVYGISHPKYRIVLKEKCPMC--VFG-
-----NTDEP-KPDAPASDTETTSEA-D-SKA----------------------------
------------------------------------------------------------
---------
>    24== X65878   1 Drosophila pseudoobscura Dpse\Rh2 <>[Genetics132(1),193-204'92
------MERSLLPEPPLAM--------------------ALLGPRFEAQTGG--------
------NRSVLD-NVL---PDM---APLVNPHWSRFAPMDPT------------------
MSKILGLFTLVILIISCCGNGVVVYIFGGTKSLRTPANLLVLNLAFSDFCM-MASQSPVM
IINFYY-ETWV--LGPLWCDIYAACGSLFGCVSIWSMCMIAFDRYNVIVKGINGT-PMTI
KTSIMKIAFIWMMAVFW-TIMPLIG-W-----SSYVPEGNLTACSIDYMTRQWN--PRSY
LITYSLFVYYTPLFMICYSYWFIIATVAAHEKAMRDQ-----------------------
-------------------AKK-----------------------------MN-------
---VKSL-----------------------------------------------------
----------------R-SSEDCDKS------AENKLAKVALTTISLWFMAWTPYLIICY
FGLF-KI-DG--LTPLTTIWGATFAKTSAVYNPIVYGISHPNDRLVLKEKCPMC--VCG-
-----TTDEP-KPDAPPSDTETTSEA-E-SKD----------------------------
------------------------------------------------------------
---------
>    25== U26026   1 Apis mellifera long-wavelength rhodopsin <>[]
------MI-------------------------------AVSGPSYEAFSYGGQARF---
-N----NQTVVD-KVP---PDM---LHLIDANWYQYPPLNPM------------------
WHGILGFVIGMLGFVSAMGNGMVVYIFLSTKSLRTPSNLFVINLAISNFLM-MFCMSPPM
VINCYY-ETWV--LGPLFCQIYAMLGSLFGCGSIWTMTMIAFDRYNVIVKGLSGK-PLSI
NGALIRIIAIWLFSLGW-TIAPMFG-W-----NRYVPEGNMTACGTDYFNRGLL--SASY
LVCYGIWVYFVPLFLIIYSYWFIIQAVAAHEKNMREQ-----------------------
-------------------AKK-----------------------------MN-------
---VASL-----------------------------------------------------
----------------R-SSENQNTS------AECKLAKVALMTISLWFMAWTPYLVINF
SGIF-NL-VK--ISPLFTIWGSLFAKANAVYNPIVYGISHPKYRAALFAKFPSL--AC--
-----AAEPS-SDAVSTTSGTTTVTD-N-EKSNA--------------------------
------------------------------------------------------------
---------
>    26== L03781   1 Limulus polyphemus opsin <>[PNAS90,6150-6154'93]
---------------------------------------MANQLSYSSLGWPYQP-----
------NASVVD-TMP---KEM---LYMIHEHWYAFPPMNPL------------------
WYSILGVAMIILGIICVLGNGMVIYLMMTTKSLRTPTNLLVVNLAFSDFCM-MAFMMPTM
TSNCFA-ETWI--LGPFMCEVYGMAGSLFGCASIWSMVMITLDRYNVIVRGMAAA-PLTH
KKATLLLLFVWIWSGGW-TILPFFG-W-----SRYVPEGNLTSCTVDYLTKDWS--SASY
VVIYGLAVYFLPLITMIYCYFFIVHAVAEHEKQLREQ-----------------------
-------------------AKK-----------------------------MN-------
---VASL-----------------------------------------------------
----------------RANADQQKQS------AECRLAKVAMMTVGLWFMAWTPYLIISW
AGVF-SSGTR--LTPLATIWGSVFAKANSCYNPIVYGISHPRYKAALYQRFPSL--ACG-
-----SGESG-SDVKSEASATTTMEE-K-PKIPEA-------------------------
------------------------------------------------------------
---------
>    27== X07797   1 Octopus dofleini rhodopsin <>[FEBS232(1),69-72'88]
-----MVESTTLVNQT----------------------------------------WW-Y
------NPTVD-----------------IHPHWAKFDPIPDA------------------
VYYSVGIFIGVVGIIGILGNGVVIYLFSKTKSLQTPANMFIINLAMSDLSFSAINGFPLK
TISAFM-KKWI--FGKVACQLYGLLGGIFGFMSINTMAMISIDRYNVIGRPMAASKKMSH
RRAFLMIIFVWMWSIVW-SVGPVFN-W-----GAYVPEGILTSCSFDYLSTDPS--TRSF
ILCMYFCGFMLPIIIIAFCYFNIVMSVSNHEKEMAAM-----------------------
-------------------AKR-----------------------------LN-------
---AKEL-----------------------------------------------------
----------------R--KAQAGAS------AEMKLAKISMVIITQFMLSWSPYAIIAL
LAQF-GPAEW--VTPYAAELPVLFAKASAIHNPIVYSVSHPKFREAIQTTFPWLLTCCQ-
-----FDEKE-CEDANDAEEEVVASE-R-GGE--SRDAAQMKEMMAMMQKMQAQQAAYQP
PPPPQGY--PPQGYPPQGA-YPPPQGYPPQGYPPQGYPPQGYPPQGAPPQVEAPQGAPPQ
GVDNQAYQA
>    28== X70498   1 Todarodes pacificus rhodopsin <retina>[FEBS317(1-2),5-11'93]
------MGRDLRDNET----------------------------------------WW-Y
------NPSIV-----------------VHPHWREFDQVPDA------------------
VYYSLGIFIGICGIIGCGGNGIVIYLFTKTKSLQTPANMFIINLAFSDFTFSLVNGFPLM
TISCFL-KKWI--FGFAACKVYGFIGGIFGFMSIMTMAMISIDRYNVIGRPMAASKKMSH
RRAFIMIIFVWLWSVLW-AIGPIFG-W-----GAYTLEGVLCNCSFDYISRDST--TRSN
ILCMFILGFFGPILIIFFCYFNIVMSVSNHEKEMAAM-----------------------
-------------------AKR-----------------------------LN-------
---AKEL-----------------------------------------------------
----------------R--KAQAGAN------AEMRLAKISIVIVSQFLLSWSPYAVVAL
LAQF-GPLEW--VTPYAAQLPVMFAKASAIHNPMIYSVSHPKFREAISQTFPWVLTCCQ-
-----FDDKE-TEDDKDAETEIPAGE-S-SDAAPSADAAQMKEMMAMMQKMQQQQAAY--
--PPQGYAPPPQGYPPQG--Y-PPQGYPPQGYPPQGYPP---PPQGAPPQ-GAPPAAPPQ
GVDNQAYQA
>    29== L21195   1 human serotonin 5-HT7 receptor protein <placenta and fetal bra
M-----MDVNSSGRPDL----YGHLRSFL--LPEVGRGLPDLSPDGG--ADPVAGSWAPH
LLS---EVTASP-APTWD------------------APPDNASG------CGEQINYGRV
EKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSV-AVAVMPFV
SVTDLIGGKWI--FGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNG
KCMAKMILSVWLLSASI-TLPPLFG-W-----AQNVNDD--KVCLIS--------QDFGY
TIYSTAVAFYIPMSVMLFMYYQIYKAA---RKSAAKHKF-------------------PG
FP---------------------------RVEPDS-------------------------
---VIAL-----------------NGIVKLQ--------KEVEECAN-------------
----------LSRLLKHERKNISIFK------REQKAATTLGIIVGAFTVCWLPFFLLST
ARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLL-----QCQY
R--------------------------NINRKLSA---AGMHEALKLAE-----------
--RPERP-----EFVLQNADYCRKKGHDS-------------------------------
---------
>    30== L15228   1 rat 5HT-7 serotonin receptor <>[JBC268,18200-18204'93]
---------------------------------------------------------MPH
LLSGFLEVTASP-APTWD------------------APPDNVSG------CGEQINYGRV
EKVVIGSILTLITLLTIAGNCLVVISVSFVKKLRQPSNYLIVSLALADLSV-AVAVMPFV
SVTDLIGGKWI--FGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNG
KCMAKMILSVWLLSASI-TLPPLFG-W-----AQNVNDD--KVCLIS--------QDFGY
TIYSTAVAFYIPMSVMLFMYYQIYKAA---RKSAAKHKF-------------------PG
FP---------------------------RVQPES-------------------------
---VISL-----------------NGVVKLQ--------KEVEECAN-------------
----------LSRLLKHERKNISIFK------REQKAATTLGIIVGAFTVCWLPFFLLST
ARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRPTSRSLL-----QCQY
R--------------------------NINRKLSA---AGMHEALKLAE-----------
--RPERS-----EFVLQNSDHCGKKGHDT-------------------------------
---------
>    31=p A47425 serotonin receptor 5HT-7 - rat
---------------------------------------------------------MPH
LLSGFLEVTASP-APTWD------------------APPDNVSG------CGEQINYGRV
EKVVIGSILTLITLLTIAGNCLVVISVSFVKKLRQPSNYLIVSLALADLSV-AVAVMPFV
SVTDLIGGKWI--FGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNG
KCMAKMILSVWLLSASI-TLPPLFG-W-----AQNVNDD--KVCLIS--------QDFGY
TIYSTAVAFYIPMSVMLFMYYQIYKAA---RKSAAKHKF-------------------PG
FP---------------------------RVQPES-------------------------
---VISL-----------------NGVVKLQ--------KEVEECAN-------------
----------LSRLLKHERKNISIFK------REQKAATTLGIIVGAFTVCWLPFFLLST
ARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLL-----QCQY
R--------------------------NINRKLSA---AGMHEALKLAE-----------
--RPERS-----EFVLQNSDHCGKKGHDT-------------------------------
---------
>    32== M83181   1 human serotonin receptor <>[JBC267(11),7553-7562'92]
------MDVLSPGQ-------------------------------G--------------
------NNTTSP-PAPFE-TG-----------GNTTGISDVTVS----------------
YQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMV-SVLVLPMA
ALYQVL-NKWT--LGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTP
RRAAALISLTWLIGFLI-SIPPMLG-WRTPE-DRSDPD----ACTIS--------KDHGY
TIYSTFGAFYIPLLLMLVLYGRIFRAA---RFRIRKT---VKKV----------------
-------------------EKTGADTRH-GASPAPQPKKS-----------VNGESGSR-
--------NWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGP
TPCA-------PASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVAL
VLPF-CESSC-HMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKII-----KCKF
C--------------------------RQ-------------------------------
------------------------------------------------------------
---------
>    33=p A35181 serotonin receptor class 1A - rat
------MDVFSFGQ-------------------------------G--------------
------NNTTAS-QEPFG-TG-----------GNVTSISDVTFS----------------
YQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMV-SVLVLPMA
ALYQVL-NKWT--LGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTP
RRAAALISLTWLIGFLI-SIPPMLG-WRTPE-DRSDPD----ACTIS--------KDHGY
TIYSTFGAFYIPLLLMLVLYGRIFRAA---RFRIRKT---VRKV----------------
-------------------EKKGAGTSL-GTSSAPPPKKS-----------LNGQPGSG-
--------DWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGS
NSYA-------PACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVAL
VLPF-CESSC-HMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKII-----KCKF
C--------------------------RR-------------------------------
------------------------------------------------------------
---------
>    34== L06803   1 Lymnaea stagnalis serotonin receptor <>[PNAS90,11-15'93]
------MANFTFGDLALDVARMGGLASTPSGLRSTGLTTPGLSPTG--------------
------LVTSDF-NDSYGLTGQFINGSHSSRSRDNASANDTSATNMTDDRYWSLTVYSHE
HLVLTSVILGLFVLCCIIGNCFVIAAVMLERSLHNVANYLILSLAVADLMV-AVLVMPLS
VVSEIS-KVWF--LHSEVCDMWISVDVLCCTASILHLVAIAMDRYWAVTS-IDYIRRRSA
RRILLMIMVVWIVALFI-SIPPLFG-WRDPNNDPDKTG----TCIIS--------QDKGY
TIFSTVGAFYLPMLVMMIIYIRIWLVA---RSRIRKDKFQMTKARLKTEETTLVASPKTE
YSVVSDCNGCNSPDSTTEKKKRRAPFKSYGCSPRPERKKNRAKKLPENANGVNSNSSS--
--------SERLKQIQIETAEAFANGCA----EEASIAMLERQ-CNNGKK-----ISSND
TPYS-------------RTREKLELK------RERKAARTLAIITGAFLICWLPFFIIAL
IGPF-VDPEG--IPPFARSFVLWLGYFNSLLNPIIYTIFSPEFRSAFQKIL-----FGKY
R--------------------------RGHR-----------------------------
------------------------------------------------------------
---------
>    35=p A47174 serotonin receptor, 5HTlym receptor - great pond snail
------MANFTFGDLALDVARMGGLASTPSGLRSTGLTTPGLSPTG--------------
------LVTSDF-NDSYGLTGQFINGSHSSRSRDNASANDTSATNMTDDRYWSLTVYSHE
HLVLTSVILGLFVLCCIIGNCFVIAAVMLERSLHNVANYLILSLAVADLMV-AVLVMPLS
VVSEIS-KVWF--LHSEVCDMWISVDVLCCTASILHLVAIAMDRYWAVTS-IDYIRRRSA
RRILLMIMVVWIVALFI-SIPPLFG-WRDPNNDPDKTG----TCIIS--------QDKGY
TIFSTVGAFYLPMLVMMIIYIRIWLVA---RSRIRKDKFQMTKARLKTEETTLVASPKTE
YSVVSDCNGCNSPDSTTEKKKRRAPFKSYGCSPRPERKKNRAKKLPENANGVNSNSSS--
--------SERLKQIQIETAEAFANGCA----EEASIAMLERQ-CNNGKK-----ISSND
TPYS-------------RTREKLELK------RERKAARTLAIITGAFLICWLPFFIIAL
IGPF-VDPEG--IPPFARSFVLWLGYFNSLLNPIIYTIFSPEFRSAFQKIL-----FGKY
R--------------------------RGHR-----------------------------
------------------------------------------------------------
---------
>    36== X95604   1 Bombyx mori serotonin receptor <antennae>[InsectBiochem.Mol.Bi
MEGAEGQEELDWEALYLRLP-----------LQNCSWNSTGWEPNW--------------
------NVTVVP-NTTW---------------WQASAPFDTPAALV--------------
RAAAKAVVLGLLILATVVGNVFVIAAILLERHLRSAANNLILSLAVADLLV-ACLVMPLG
AVYEVV-QRWT--LGPELCDMWTSGDVLCCTASILHLVAIALDRYWAVTN-IDYIHASTA
KRVGMMIACVWTVSFFV-CIAQLLG-WKDPDWNQRVSED--LRCVVS--------QDVGY
QIFATASSFYVPVLIILILYWRIYQTA---RKRIR-------------------------
-------------------RRRGATARG-GVGPPP---------VPAGGALVAGGGSGGI
AAAVVAVIGRPLPTISETTTTGFTNVSS----NNTS---PEKQSCANGLE-----ADPPT
TGYGAVAAAYYPSLVRRKPKEAADSK------RERKAAKTLAIITGAFVACWLPFFVLAI
LVPT-CDCE---VSPVLTSLSLWLGYFNSTLNPVIYTVFSPEFRHAFQRLL-----CGRR
V--------------------------RRRRA----------------------------
---PQ-------------------------------------------------------
---------
