>     1== M63632   1 Lampetra japonica rhodopsin <>[BBRC174,1125-1132'91]
--------------MN-----------GTE-G--------D-------------------
--------------------N------------FYVP------------FSNKTGLA---
---RSPYEY---------PQ-------YY-LAEPWKYSALAAYMFFLILVGFPVNFLTLF
VTVQHKKLRTPLNYILLNLAMANLFMVLFG-FTVTMYTSMN-GYFV--FGPTMCSIEGFF
ATLGGEVALWSLVVLAIERYIVICKPMGN-FRFGNTHAIMGVAFTWIMALAC-AAPPLVG
-WSRYIPEGMQCSCGPDYYTL--NPNFNNESYVVYMFVVHFLVPFVIIFFCYGRLLCTVK
EAAAAQQ-----------------------------------------------------
------------------------------------------------E-----------
------------------SASTQK------------------------------------
-----AEKEVTRMVVLMVIGFLVCWVPYASVAFYIFT-HQGSD-FGATFM-TLPAFFAKS
SALYNPVIYILMNKQFRNCMITT----LCCG------KN--------PLGDDE--SGAST
SKT---------EVSSVS-----------TSPVS--------------------------
------------------PA-------------------------
>     2== U22180   1 rat opsin <rod>[J.Mol.Neurosci.5(3),207-209'94]
--------------MN-----------GTE-G--------P-------------------
--------------------N------------FYVP------------FSNITGVV---
---RSPFEQ---------PQ-------YY-LAEPWQFSMLAAYMFLLIVLGFPINFLTLY
VTVQHKKLRTPLNYILLNLAVADLFMVFGG-FTTTLYTSLH-GYFV--FGPTGCNLEGFF
ATLGGEIGLWSLVVLAIERYVVVCKPMSN-FRFGENHAIMGVAFTWVMALAC-AAPPLVG
-WSRYIPEGMQCSCGIDYYTL--KPEVNNESFVIYMFVVHFTIPMIVIFFCYGQLVFTVK
EAAAQQQ-----------------------------------------------------
------------------------------------------------E-----------
------------------SATTQK------------------------------------
-----AEKEVTRMVIIMVIFFLICWLPYASVAMYIFT-HQGSN-FGPIFM-TLPAFFAKT
ASIYNPIIYIMMNKQFRNCMLTS----LCCG------KN--------PLGDDE--ASATA
SKT---------E----------------TSQVA--------------------------
------------------PA-------------------------
>     3== M92038   1 chicken green sensitive cone opsin <retina>[PNAS89,5932-5936'9
--------------MN-----------GTE-G--------I-------------------
--------------------N------------FYVP------------MSNKTGVV---
---RSPFEY---------PQ-------YY-LAEPWKYRLVCCYIFFLISTGLPINLLTLL
VTFKHKKLRQPLNYILVNLAVADLFMACFG-FTVTFYTAWN-GYFV--FGPVGCAVEGFF
ATLGGQVALWSLVVLAIERYIVVCKPMGN-FRFSATHAMMGIAFTWVMAFSC-AAPPLFG
-WSRYMPEGMQCSCGPDYYTH--NPDYHNESYVLYMFVIHFIIPVVVIFFSYGRLICKVR
EAAAQQQ-----------------------------------------------------
------------------------------------------------E-----------
------------------SATTQK------------------------------------
-----AEKEVTRMVILMVLGFMLAWTPYAVVAFWIFT-NKGAD-FTATLM-AVPAFFSKS
SSLYNPIIYVLMNKQFRNCMITT----ICCG------KN--------PFGDEDVSSTVSQ
SKT---------EVSSVS-----------SSQVS--------------------------
------------------PA-------------------------
>     4=p A45229 opsin, green-sensitive (clone GFgr-1) - goldfish
--------------MN-----------GTE-G--------K-------------------
--------------------N------------FYVP------------MSNRTGLV---
---RSPFEY---------PQ-------YY-LAEPWQFKILALYLFFLMSMGLPINGLTLV
VTAQHKKLRQPLNFILVNLAVAGTIMVCFG-FTVTFYTAIN-GYFV--LGPTGCAVEGFM
ATLGGEVALWSLVVLAIERYIVVCKPMGS-FKFSSSHAFAGIAFTWVMALAC-AAPPLFG
-WSRYIPEGMQCSCGPDYYTL--NPDYNNESYVIYMFVCHFILPVAVIFFTYGRLVCTVK
AAAAQQQ-----------------------------------------------------
------------------------------------------------D-----------
------------------SASTQK------------------------------------
-----AEREVTKMVILMVFGFLIAWTPYATVAAWIFF-NKGAD-FSAKFM-AIPAFFSKS
SALYNPVIYVLLNKQFRNCMLTT----IFCG------KN--------PLGDDE-SSTVST
SKT---------EVSS----------------VS--------------------------
------------------PA-------------------------
>     5=p B45229 opsin, green-sensitive (clone GFgr-2) - goldfish
--------------MN-----------GTE-G--------N-------------------
--------------------N------------FYVP------------LSNRTGLV---
---RSPFEY---------PQ-------YY-LAEPWQFKLLAVYMFFLICLGLPINGLTLI
CTAQHKKLRQPLNFILVNLAVAGAIMVCFG-FTVTFYTAIN-GYFA--LGPTGCAVEGFM
ATLGGEVALWSLVVLAIERYIVVCKPMGS-FKFSSTHASAGIAFTWVMAMAC-AAPPLVG
-WSRYIPEGIQCSCGPDYYTL--NPEYNNESYVLYMFICHFILPVTIIFFTYGRLVCTVK
AAAAQQQ-----------------------------------------------------
------------------------------------------------D-----------
------------------SASTQK------------------------------------
-----AEREVTKMVILMVLGFLVAWTPYATVAAWIFF-NKGAA-FSAQFM-AIPAFFSKT
SALYNPVIYVLLNKQFRSCMLTT----LFCG------KN--------PLGDEE-SSTVST
SKT---------EVSS----------------VS--------------------------
------------------PA-------------------------
>     6== L11864   1 Carassius auratus blue cone opsin <retina>[Biochemistry32,208-
-------------MKQ-----------VPEFH--------E-------------------
--------------------D------------FYIPI--------PLDINNLSA-----
---YSPFLV---------PQ-------DH-LGNQGIFMAMSVFMFFIFIGGASINILTIL
CTIQFKKLRSHLNYILVNLSIANLFVAIFG-SPLSFYSFFN-RYFI--FGATACKIEGFL
ATLGGMVGLWSLAVVAFERWLVICKPLGN-FTFKTPHAIAGCILPWISALAA-SLPPLFG
-WSRYIPEGLQCSCGPDWYTT--NNKYNNESYVMFLFCFCFAVPFGTIVFCYGQLLITLK
LAAKAQA-----------------------------------------------------
------------------------------------------------D-----------
------------------SASTQK------------------------------------
-----AEREVTKMVVVMVLGFLVCWAPYASFSLWIVS-HRGEE-FDLRMA-TIPSCLSKA
STVYNPVIYVLMNKQFRSCMM-K----MVCG------KN---------IEEDE--ASTSS
QVT---------QVSS----------------VA--------------------------
------------------PEK------------------------
>     7== M13299   1 human BCP <>[Science232(4747),193-202'86]
-------------MRK-----------MSE----------E-------------------
--------------------E------------FYL-------------FKNISSV----
----GPWDG---------PQ-------YH-IAPVWAFYLQAAFMGTVFLIGFPLNAMVLV
ATLRYKKLRQPLNYILVNVSFGGFLLCIFS-VFPVFVASCN-GYFV--FGRHVCALEGFL
GTVAGLVTGWSLAFLAFERYIVICKPFGN-FRFSSKHALTVVLATWTIGIGV-SIPPFFG
-WSRFIPEGLQCSCGPDWYTV--GTKYRSESYTWFLFIFCFIVPLSLICFSYTQLLRALK
AVAAQQQ-----------------------------------------------------
------------------------------------------------E-----------
------------------SATTQK------------------------------------
-----AEREVSRMVVVMVGSFCVCYVPYAAFAMYMVN-NRNHG-LDLRLV-TIPSFFSKS
ACIYNPIIYCFMNKQFQACIM-K----MVCG------KA---------MTDES--DTCSS
QKT---------EVSTVS-----------STQVG--------------------------
------------------PN-------------------------
>     8=opsin, greensensitive  human (fragment) S07060
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------DLAETVIA-STISIVNQVS-GYFV--LGHPMCVLEGYT
VSLCGITGLWSLAIISWERWLVVCKPFGN-VRFDAKLAIVGIAFSWIWAAVW-TAPPIFG
-WSRYWPHGLKTSCGPDVFSG--SSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAIR
AVAKQQK-----------------------------------------------------
------------------------------------------------E-----------
------------------SESTQK------------------------------------
-----AEKEVTRMVVVMVLAFC--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------
>     9== K03494   1 human GCP <>[Science232(4747),193-202'86]
--MAQQWSLQRLAGRH-----------PQD-S-------YE-------------------
--------------------D-----STQSSIFTYT-------------NSNST------
---RGPFEG---------PN-------YH-IAPRWVYHLTSVWMIFVVIASVFTNGLVLA
ATMKFKKLRHPLNWILVNLAVADLAETVIA-STISVVNQVY-GYFV--LGHPMCVLEGYT
VSLCGITGLWSLAIISWERWMVVCKPFGN-VRFDAKLAIVGIAFSWIWAAVW-TAPPIFG
-WSRYWPHGLKTSCGPDVFSG--SSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAIR
AVAKQQK-----------------------------------------------------
------------------------------------------------E-----------
------------------SESTQK------------------------------------
-----AEKEVTRMVVVMVLAFCFCWGPYAFFACFAAA-NPGYP-FHPLMA-ALPAFFAKS
ATIYNPVIYVFMNRQFRNCILQL----FG--------KK---------VDDGS--ELSSA
SKT---------EVSSV-------------SSVS--------------------------
------------------PA-------------------------
>    10== Z68193   1 human Red Opsin <>[]
--MAQQWSLQRLAGRH-----------PQD-S-------YE-------------------
--------------------D-----STQSSIFTYT-------------NSNST------
---RGPFEG---------PN-------YH-IAPRWVYHLTSVWMIFVVTASVFTNGLVLA
ATMKFKKLRHPLNWILVNLAVADLAETVIA-STISIVNQVS-GYFV--LGHPMCVLEGYT
VSLCGITGLWSLAIISWERWLVVCKPFGN-VRFDAKLAIVGIAFSWIWSAVW-TAPPIFG
-WSRYWPHGLKTSCGPDVFSG--SSYPGVQSYMIVLMVTCCIIPLAIIMLCYLQVWLAIR
AVAKQQK-----------------------------------------------------
------------------------------------------------E-----------
------------------SESTQK------------------------------------
-----AEKEVTRMVVVMIFAYCVCWGPYTFFACFAAA-NPGYA-FHPLMA-ALPAYFAKS
ATIYNPVIYVFMNRQFRNCILQL----FG--------KK---------VDDGS--ELSSA
SKT---------EVSSV-------------SSVS--------------------------
------------------PA-------------------------
>    11== M92036   1 Gecko gecko P521 <retina>[PNAS89,6841-6845'92]
MTEAWNVAV--FAARR-----------SRD-D--------D-------------------
--------------------D-----TTRGSVFTYT-------------NTNNT------
---RGPFEG---------PN-------YH-IAPRWVYNLVSFFMIIVVIASCFTNGLVLV
ATAKFKKLRHPLNWILVNLAFVDLVETLVA-STISVFNQIF-GYFI--LGHPLCVIEGYV
VSSCGITGLWSLAIISWERWFVVCKPFGN-IKFDSKLAIIGIVFSWVWAWGW-SAPPIFG
-WSRYWPHGLKTSCGPDVFSG--SVELGCQSFMLTLMITCCFLPLFIIIVCYLQVWMAIR
AVAAQQK-----------------------------------------------------
------------------------------------------------E-----------
------------------SESTQK------------------------------------
-----AEREVSRMVVVMIVAFCICWGPYASFVSFAAA-NPGYA-FHPLAA-ALPAYFAKS
ATIYNPVIYVFMNRQFRNCIMQL----FG--------KK---------VDDGS--EASTT
SRT---------EVSSVS-----------NSSVA--------------------------
------------------PA-------------------------
>    12== M62903   1 chicken visual pigment <>[BBRC173,1212-1217'90]
-MAAWEAA---FAARR-----------RHE-E--------E-------------------
--------------------D-----TTRDSVFTYT-------------NSNNT------
---RGPFEG---------PN-------YH-IAPRWVYNLTSVWMIFVVAASVFTNGLVLV
ATWKFKKLRHPLNWILVNLAVADLGETVIA-STISVINQIS-GYFI--LGHPMCVVEGYT
VSACGITALWSLAIISWERWFVVCKPFGN-IKFDGKLAVAGILFSWLWSCAW-TAPPIFG
-WSRYWPHGLKTSCGPDVFSG--SSDPGVQSYMVVLMVTCCFFPLAIIILCYLQVWLAIR
AVAAQQK-----------------------------------------------------
------------------------------------------------E-----------
------------------SESTQK------------------------------------
-----AEKEVSRMVVVMIVAYCFCWGPYTFFACFAAA-NPGYA-FHPLAA-ALPAYFAKS
ATIYNPIIYVFMNRQFRNCILQL----FG--------KK---------VDDGS--EVST-
SRT---------EVSSVS-----------NSSVS--------------------------
------------------PA-------------------------
>    13== S75720   1 chicken P-opsin <>[Science267(5203),1502-1506'95]
------MS--------------------------------S-------------------
--------------------N-----SSQAP-------------------PNGT------
---PGPFDG---------PQW-----PYQ--APQSTYVGVAVLMGTVVACASVVNGLVIV
VSICYKKLRSPLNYILVNLAVADLLVTLCG-SSVSLSNNIN-GFFV--FGRRMCELEGFM
VSLTGIVGLWSLAILALERYVVVCKPLGD-FQFQRRHAVSGCAFTWGWALLW-SAPPLLG
-WSSYVPEGLRTSCGPNWYTG--GSNN--NSYILSLFVTCFVLPLSLILFSYTNLLLTLR
AAAAQQK-----------------------------------------------------
------------------------------------------------E-----------
------------------ADTTQR------------------------------------
-----AEREVTRMVIVMVMAFLLCWLPYSTFALVVAT-HKGII-IQPVLA-SLPSYFSKT
ATVYNPIIYVFMNKQFQSCLLEM----LCCGYQ---PQR---------TGKAS--PGTPG
PHA---------DVTAAG----------LRNKVM--------------------------
------------------PAHPV----------------------
>    14== M17718   1 D.melanogaster Rh3 <>[J.Neurosci.7,1550-1557'87]
----------------------------MESGNV-SSSLFG-------------------
--------------------N-----VS-TAL-----------RP-EAR-LSA---ETRL
LGWNVPPE----ELRHIPEHW----LTYP-EPPESMNYLLGTLYIFFTLMSMLGNGLVIW
VFSAAKSLRTPSNILVINLAFCDF-MMMVK-TPIFIYNSFH-QGYA--LGHLGCQIFGII
GSYTGIAAGATNAFIAYDRFNVITRPMEG--KMTHGKAIAMIIFIYMYATPW-VVACYTE
TWGRFVPEGYLTSCTFDYLTD----NFDTRLFVACIFFFSFVCPTTMITYYYSQI---VG
HVFSHEK-----------------------------------------------------
------------------------------------------------AL----------
------------------RDQAKKMNV---------------------ESLRSNVDKNKE
T----AEIRIAKAAITICFLFFCSWTPYGVMSLIGAF-GDKTL-LTPGAT-MIPACACKM
VACIDPFVYAISHPRYRMELQKRCPW--------------------LALNEKA-PESSAV
ASTS------TTQEP---------------QQTT--------------------------
---------------------------AA----------------
>    15== X65879   1 Drosophila pseudoobscura Dpse\Rh3 <>[Genetics132(1),193-204'92
----------------------------MEYHNV-SSVL-G-------------------
--------------------N-----VS-SVL-----------RP-DAR-LSA---ESRL
LGWNVPPD----ELRHIPEHW----LIYP-EPPESMNYLLGTLYIFFTVISMIGNGLVMW
VFSAAKSLRTPSNILVINLAFCDF-MMMIK-TPIFIYNSFH-QGYA--LGHLGCQIFGVI
GSYTGIAAGATNAFIAYDRYNVITRPMEG--KMTHGKAIAMIIFIYLYATPW-VVACYTE
SWGRFVPEGYLTSCTFDYLTD----NFDTRLFVACIFFFSFVCPTTMITYYYSQI---VG
HVFSHEK-----------------------------------------------------
------------------------------------------------AL----------
------------------RDQAKKMNV---------------------DSLRSNVDKSKE
A----AEIRIAKAAITICFLFFASWTPYGVMSLIGAF-GDKTL-LTPGAT-MIPACTCKM
VACIDPFVYAISHPRYRMELQKRCPW--------------------LAISEKA-PESRAA
ISTS------TTQEQ---------------QQTT--------------------------
---------------------------AA----------------
>    16== M17730   1 D.melanogaster Rh4 opsin <>[J.Neurosci.7,1558-1566'87]
----------------------------ME-------PL-C-------------------
--------------------N-----ASEPPL-----------RP-EAR--SSGNGDLQF
LGWNVPPD----QIQYIPEHW----LTQL-EPPASMHYMLGVFYIFLFCASTVGNGMVIW
IFSTSKSLRTPSNMFVLNLAVFDL-IMCLK-APIF--NSFH-RGFAIYLGNTWCQIFASI
GSYSGIGAGMTNAAIGYDRYNVITKPMNR--NMTFTKAVIMNIIIWLYCTPW-VVLPLTQ
FWDRFVPEGYLTSCSFDYLSD----NFDTRLFVGTIFFFSFVCPTLMILYYYSQI---VG
HVFSHEK-----------------------------------------------------
------------------------------------------------AL----------
------------------REQAKKMNV---------------------ESLRSNVDKSKE
T----AEIRIAKAAITICFLFFVSWTPYGVMSLIGAF-GDKSL-LTQGAT-MIPACTCKL
VACIDPFVYAISHPRYRLELQKRCPW--------------------LGVNEKS-GEISSA
QST-------TTQEQ---------------QQTT--------------------------
---------------------------AA----------------
>    17== X65880   1 Drosophila pseudoobscura Dpse\Rh4 <>[Genetics132(1),193-204'92
----------------------------MD-------AL-C-------------------
--------------------N-----ASEPPL-----------RP-EAR-MSSGSDELQF
LGWNVPPD----QIQYIPEHW----LTQL-EPPASMHYMLGVFYIFLFFASTLGNGMVIW
IFSTSKSLRTPSNMFVLNLAVFDL-IMCLK-APIFIYNSFH-RGFA--LGNTWCQIFASI
GSYSGIGAGMTNAAIGYDRYNVITKPMNR--NMTFTKAVIMNIIIWLYCTPW-VVLPLTQ
FWDRFVPEGYLTSCSFDYLSD----NFDTRLFVGTIFLFSFVVPTLMILYYYSQI---VG
HVFNHEK-----------------------------------------------------
------------------------------------------------AL----------
------------------REQAKKMNV---------------------ESLRSNVDKSKE
T----AEIRIAKAAITICFLFFVSWTPYGVMSLIGAF-GDKSL-LTPGAT-MIPACTCKL
VACIEPFVYAISHPRYRMELQKRCPW--------------------LGVNEKS-GEASSA
QST-------TTQEQT--------------QQTS--------------------------
---------------------------AA----------------
>    18== D50584   1 Hemigrapsus sanguineus opsin BcRh2 <compound eye>[J.Exp.Biol.1
---------------------------------------MT-------------------
--------------------N-----ATGPQMAYYGAASMDFGYP-EGV----SIVD---
---FVRPE-IKPYVH---QHW----YNYP-PVNPMWHYLLGVIYLFLGTVSIFGNGLVIY
LFNKSAALRTPANILVVNLALSDLIMLTTN-VPFFTYNCFSGGVWM--FSPQYCEIYACL
GAITGVCSIWLLCMISFDRYNIICNGFNG-PKLTTGKAVVFALISWVIAIGC-ALPPFFG
-WGNYILEGILDSCSYDYLTQ----DFNTFSYNIFIFVFDYFLPAAIIVFSYVFI---VK
AIFAHEA-----------------------------------------------------
------------------------------------------------AM----------
------------------RAQAKKMNV---------------------STLR-SNEADAQ
R----AEIRIAKTALVNVSLWFICWTPYALISLKGVM-GDTSG-ITPLVS-TLPALLAKS
CSCYNPFVYAISHPKYRLAITQHLPW-FCVH-ETE------------TKSNDD-SQSNST
VA----------QDKA--------------------------------------------
---------------------------------------------
>    19== D50583   1 Hemigrapsus sanguineus opsin BcRh1 <compound eye>[J.Exp.Biol.1
---------------------------------------MA-------------------
--------------------N-----VTGPQMAFYGSGAATFGYP-EGM----TVAD---
---FV-PDRVK---HMVLDHW----YNYP-PVNPMWHYLLGVVYLFLGVISIAGNGLVIY
LYMKSQALKTPANMLIVNLALSDLIMLTTN-FPPFCYNCFSGGRWM--FSGTYCEIYAAL
GAITGVCSIWTLCMISFDRYNIICNGFNG-PKLTQGKATFMCGLAWVISVGW-SLPPFFG
-WGSYTLEGILDSCSYDYFTR----DMNTITYNICIFIFDFFLPASVIVFSYVFI---VK
AIFAHEA-----------------------------------------------------
------------------------------------------------AM----------
------------------RAQAKKMNV---------------------TNLR-SNEAETQ
R----AEIRIAKTALVNVSLWFICWTPYAAITIQGLL-GNAEG-ITPLLT-TLPALLAKS
CSCYNPFVYAISHPKFRLAITQHLPW-FCVH-EKD------------PNDVEE-NQSSNT
QT----------QEKS--------------------------------------------
---------------------------------------------
>    20== K02320   1 D.melanogaster opsin <>[Cell40,851-858'85]
----------------------------MESF-----AVAA-------------------
--------------------A-----QLGPH---FAP---------LS---NGSVVD---
---KVTPD----MAHLISPYW----NQFP-AMDPIWAKILTAYMIMIGMISWCGNGVVIY
IFATTKSLRTPANLLVINLAISDFGIMITN-TPMMGINLYF-ETWV--LGPMMCDIYAGL
GSAFGCSSIWSMCMISLDRYQVIVKGMAG-RPMTIPLALGKM------------------
----YVPEGNLTSCGIDYLER----DWNPRSYLIFYSIFVYYIPLFLICYSYWFI---IA
AVSAHEK-----------------------------------------------------
------------------------------------------------AM----------
------------------REQAKKMNV---------------------KSLR-SSEDAEK
S----AEGKLAKVALVTITLWFMAWTPYLVINCMGLF-KF-EG-LTPLNT-IWGACFAKS
AACYNPIVYGISHPKYRLALKEKCPC-CVFG-KVDDGK----------SSDAQ-SQATAS
EA----------ESKA--------------------------------------------
---------------------------------------------
>    21== K02315   1 D.melanogaster ninaE <>[Cell40,839-850'85]
----------------------------MESF-----AVAA-------------------
--------------------A-----QLGPH---FAP---------LS---NGSVVD---
---KVTPD----MAHLISPYW----NQFP-AMDPIWAKILTAYMIMIGMISWCGNGVVIY
IFATTKSLRTPANLLVINLAISDFGIMITN-TPMMGINLYF-ETWV--LGPMMCDIYAGL
GSAFGCSSIWSMCMISLDRYQVIVKGMAG-RPMTIPLALGKIAYIWFMSSIW-CLAPAFG
-WSRYVPEGNLTSCGIDYLER----DWNPRSYLIFYSIFVYYIPLFLICYSYWFI---IA
AVSAHEK-----------------------------------------------------
------------------------------------------------AM----------
------------------REQAKKMNV---------------------KSLR-SSEDAEK
S----AEGKLAKVALVTITLWFMAWTPYLVINCMGLF-KF-EG-LTPLNT-IWGACFAKS
AACYNPIVYGISHPKYRLALKEKCPC-CVFG-KVDDGK----------SSDAQ-SQATAS
EA----------ESKA--------------------------------------------
---------------------------------------------
>    22== X65877   1 Drosophila pseudoobscura Dpse\ninaE <>[Genetics132(1),193-204'
----------------------------MDSF-----AAVA-------------------
--------------------T-----QLGPQ---FAA---------PS---NGSVVD---
---KVTPD----MAHLISPYW----DQFP-AMDPIWAKILTAYMIIIGMISWCGNGVVIY
IFATTKSLRTPANLLVINLAISDFGIMITN-TPMMGINLYF-ETWV--LGPMMCDIYAGL
GSAFGCSSIWSMCMISLDRYQVIVKGMAG-RPMTIPLALGKIAYIWFMSTIWCCLAPVFG
-WSRYVPEGNLTSCGIDYLER----DWNPRSYLIFYSIFVYYIPLFLICYSYWFI---IA
AVSAHEK-----------------------------------------------------
------------------------------------------------AM----------
------------------REQAKKMNV---------------------KSLR-SSEDADK
S----AEGKLAKVALVTISLWFMAWTPYLVINCMGLF-KF-EG-LTPLNT-IWGACFAKS
AACYNPIVYGISHPKYRLALKEKCPC-CVFG-KVDDGK----------SSEAQ-SQATTS
EA----------ESKA--------------------------------------------
---------------------------------------------
>    23== M12896   1 D.melanogaster Rh2 <>[Cell44,705-710'86]
----------------------------MERSHLPETPFDL-------------------
--------------------A-----HSGPR---FQA---------QSS-GNGSVLD---
---NVLPD----MAHLVNPYW----SRFA-PMDPMMSKILGLFTLAIMIISCCGNGVVVY
IFGGTKSLRTPANLLVLNLAFSDFCMMASQ-SPVMIINFYY-ETWV--LGPLWCDIYAGC
GSLFGCVSIWSMCMIAFDRYNVIVKGING-TPMTIKTSIMKILFIWMMAVFW-TVMPLIG
-WSAYVPEGNLTACSIDYMTR----MWNPRSYLITYSLFVYYTPLFLICYSYWFI---IA
AVAAHEK-----------------------------------------------------
------------------------------------------------AM----------
------------------REQAKKMNV---------------------KSLR-SSEDCDK
S----AEGKLAKVALTTISLWFMAWTPYLVICYFGLF-KI-DG-LTPLTT-IWGATFAKT
SAVYNPIVYGISHPKYRIVLKEKCPM-CVFG-NTDEPKPD------APASDTE----TTS
EA----------DSKA--------------------------------------------
---------------------------------------------
>    24== X65878   1 Drosophila pseudoobscura Dpse\Rh2 <>[Genetics132(1),193-204'92
----------------------------MERSLLPEPPLAM-------------------
--------------------A-----LLGPR---FEA---------QTG-GNRSVLD---
---NVLPD----MAPLVNPHW----SRFA-PMDPTMSKILGLFTLVILIISCCGNGVVVY
IFGGTKSLRTPANLLVLNLAFSDFCMMASQ-SPVMIINFYY-ETWV--LGPLWCDIYAAC
GSLFGCVSIWSMCMIAFDRYNVIVKGING-TPMTIKTSIMKIAFIWMMAVFW-TIMPLIG
-WSSYVPEGNLTACSIDYMTR----QWNPRSYLITYSLFVYYTPLFMICYSYWFI---IA
TVAAHEK-----------------------------------------------------
------------------------------------------------AM----------
------------------RDQAKKMNV---------------------KSLR-SSEDCDK
S----AENKLAKVALTTISLWFMAWTPYLIICYFGLF-KI-DG-LTPLTT-IWGATFAKT
SAVYNPIVYGISHPNDRLVLKEKCPM-CVCG-TTDEPKPD------APPSDTE----TTS
EA----------ESKD--------------------------------------------
---------------------------------------------
>    25== U26026   1 Apis mellifera long-wavelength rhodopsin <>[]
---------------------------------------MI-------------------
--------------------A-----VSGPS---YEAFS----YGGQARFNNQTVVD---
---KVPPD----MLHLIDANW----YQYP-PLNPMWHGILGFVIGMLGFVSAMGNGMVVY
IFLSTKSLRTPSNLFVINLAISNFLMMFCM-SPPMVINCYY-ETWV--LGPLFCQIYAML
GSLFGCGSIWTMTMIAFDRYNVIVKGLSG-KPLSINGALIRIIAIWLFSLGW-TIAPMFG
-WNRYVPEGNMTACGTDYFNR----GLLSASYLVCYGIWVYFVPLFLIIYSYWFI---IQ
AVAAHEK-----------------------------------------------------
------------------------------------------------NM----------
------------------REQAKKMNV---------------------ASLR-SSENQNT
S----AECKLAKVALMTISLWFMAWTPYLVINFSGIF-NL-VK-ISPLFT-IWGSLFAKA
NAVYNPIVYGISHPKYRAALFAKFPS-LAC--AAE------------PSSDAV-STTSGT
TTVT-------DNEKSNA------------------------------------------
---------------------------------------------
>    26== L03781   1 Limulus polyphemus opsin <>[PNAS90,6150-6154'93]
------------------------------------------------------------
--------------------M-----ANQLS---YSSLGW--PY--QP---NASVVD---
---TMPKE----MLYMIHEHW----YAFP-PMNPLWYSILGVAMIILGIICVLGNGMVIY
LMMTTKSLRTPTNLLVVNLAFSDFCMMAFM-MPTMTSNCFA-ETWI--LGPFMCEVYGMA
GSLFGCASIWSMVMITLDRYNVIVRGMAA-APLTHKKATLLLLFVWIWSGGW-TILPFFG
-WSRYVPEGNLTSCTVDYLTK----DWSSASYVVIYGLAVYFLPLITMIYCYFFI---VH
AVAEHEK-----------------------------------------------------
------------------------------------------------QL----------
------------------REQAKKMNV---------------------ASLRANADQQKQ
S----AECRLAKVAMMTVGLWFMAWTPYLIISWAGVF-SSGTR-LTPLAT-IWGSVFAKA
NSCYNPIVYGISHPRYKAALYQRFPS-LACG-SGE------------SGSDVK-SEASAT
TTM---------EEKPKI------------------------------------------
------------------P--------EA----------------
>    27== X07797   1 Octopus dofleini rhodopsin <>[FEBS232(1),69-72'88]
--------------------------------------MVE-------------------
--------------------S-----TTLVN---------------QTWWYNPTV-----
------------DIH---PHW----AKFD-PIPDAVYYSVGIFIGVVGIIGILGNGVVIY
LFSKTKSLQTPANMFIINLAMSDLSFSAINGFPLKTISAFM-KKWI--FGKVACQLYGLL
GGIFGFMSINTMAMISIDRYNVIGRPMAASKKMSHRRAFLMIIFVWMWSIVW-SVGPVFN
-WGAYVPEGILTSCSFDYLST----DPSTRSFILCMYFCGFMLPIIIIAFCYFNI---VM
SVSNHEK-----------------------------------------------------
------------------------------------------------EM----------
------------------AAMAKRLNA---------------------KELR-KAQAGA-
S----AEMKLAKISMVIITQFMLSWSPYAIIALLAQF-GPAEW-VTPYAA-ELPVLFAKA
SAIHNPIVYSVSHPKFREAIQTTFPWLLTCC-QFDE-KEC------EDANDAE-EEVVAS
ERGGE--SRDAAQMKEMMAMMQK----MQAQQAAYQPPPPPQGY--PPQGYPPQGAYPPP
QGYPPQGYPPQGYPPQGYPPQGAPPQVEAPQGAPPQGVDNQAYQA
>    28== X70498   1 Todarodes pacificus rhodopsin <retina>[FEBS317(1-2),5-11'93]
---------------------------------------MG-------------------
--------------------R-----DLRDN---------------ETWWYNPSI-----
------------VVH---PHW----REFD-QVPDAVYYSLGIFIGICGIIGCGGNGIVIY
LFTKTKSLQTPANMFIINLAFSDFTFSLVNGFPLMTISCFL-KKWI--FGFAACKVYGFI
GGIFGFMSIMTMAMISIDRYNVIGRPMAASKKMSHRRAFIMIIFVWLWSVLW-AIGPIFG
-WGAYTLEGVLCNCSFDYISR----DSTTRSNILCMFILGFFGPILIIFFCYFNI---VM
SVSNHEK-----------------------------------------------------
------------------------------------------------EM----------
------------------AAMAKRLNA---------------------KELR-KAQAGA-
N----AEMRLAKISIVIVSQFLLSWSPYAVVALLAQF-GPLEW-VTPYAA-QLPVMFAKA
SAIHNPMIYSVSHPKFREAISQTFPWVLTCC-QFDD-KET------EDDKDAE-TEIPAG
ESSDAAPSADAAQMKEMMAMMQK----MQQQQAAY----PPQGYAPPPQGYPPQG-Y-PP
QGYPPQGYPPQGYPP---PPQGAPPQ-GAPPAAPPQGVDNQAYQA
>    29== L21195   1 human serotonin 5-HT7 receptor protein <placenta and fetal bra
---------------------------MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSP
DG--GADPVAGS-WAP-HLLS---EVTASPA------------PTWDAPPDNASGCG---
-------EQI----------------NYG----RVEKVVIGSILTLITLLTIAGNCLVVI
SVCFVKKLRQPSNYLIVSLALADLSVAVAV-MPFVSVTDLIGGKWI--FGHFFCNVFIAM
DVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASI-TLPPLFG
-W----AQN----VNDDKV----CLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAAR
KSAAKHKF---------------------------------PG-------------F---
---PRVEP----------------------------------------DS----VIALNG
IVKLQKE------VEE--CANLSRLL----------------------KHERKNISIFK-
-----REQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYA
NSLINPFIYAFFNRDLRTTYRS-----LLQC------QYRNINRKLSAAGMHE--ALKLA
ERP---------ERPEFV--LQNADYCRKKGHDS--------------------------
---------------------------------------------
>    30== L15228   1 rat 5HT-7 serotonin receptor <>[JBC268,18200-18204'93]
------------------------------------------------------------
--------------MP-HLLSGFLEVTASPA------------PTWDAPPDNVSGCG---
-------EQI----------------NYG----RVEKVVIGSILTLITLLTIAGNCLVVI
SVSFVKKLRQPSNYLIVSLALADLSVAVAV-MPFVSVTDLIGGKWI--FGHFFCNVFIAM
DVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASI-TLPPLFG
-W----AQN----VNDDKV----CLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAAR
KSAAKHKF---------------------------------PG-------------F---
---PRVQP----------------------------------------ES----VISLNG
VVKLQKE------VEE--CANLSRLL----------------------KHERKNISIFK-
-----REQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYA
NSLINPFIYAFFNRDLRPTSRS-----LLQC------QYRNINRKLSAAGMHE--ALKLA
ERP---------ERSEFV--LQNSDHCGKKGHDT--------------------------
---------------------------------------------
>    31=p A47425 serotonin receptor 5HT-7 - rat
------------------------------------------------------------
--------------MP-HLLSGFLEVTASPA------------PTWDAPPDNVSGCG---
-------EQI----------------NYG----RVEKVVIGSILTLITLLTIAGNCLVVI
SVSFVKKLRQPSNYLIVSLALADLSVAVAV-MPFVSVTDLIGGKWI--FGHFFCNVFIAM
DVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASI-TLPPLFG
-W----AQN----VNDDKV----CLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAAR
KSAAKHKF---------------------------------PG-------------F---
---PRVQP----------------------------------------ES----VISLNG
VVKLQKE------VEE--CANLSRLL----------------------KHERKNISIFK-
-----REQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYA
NSLINPFIYAFFNRDLRTTYRS-----LLQC------QYRNINRKLSAAGMHE--ALKLA
ERP---------ERSEFV--LQNSDHCGKKGHDT--------------------------
---------------------------------------------
>    32== M83181   1 human serotonin receptor <>[JBC267(11),7553-7562'92]
----------------------------MDVLSPGQG-----------------------
------N-------------N-----TTSPP------------APFE-TGGNTTGIS---
-------DVT---------------VSYQ--------VITSLLLGTLIFCAVLGNACVVA
AIALERSLQNVANYLIGSLAVTDLMVSVLV-LPMAALYQVL-NKWT--LGQVTCDLFIAL
DVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLI-SIPPMLG
-WRT--PEDR---SDPDA-----CTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAAR
FRIRK----TVK---KVEKTG------------ADTRHGASPA-----------------
---PQ--P--KKS----------------VNGESGSRNW-RL----GVESKAGGALCANG
AVRQGDDGAALEVIEVHRVGNSKE----HLPLP-SEAGPTPCAPASFERKNERNAEA-KR
KMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPF-CESSC-HMPTLLGAIINWLGYS
NSLLNPVIYAYFNKDFQNAFKK-----IIKC------KFC--------------------
-----------------------------RQ-----------------------------
---------------------------------------------
>    33=p A35181 serotonin receptor class 1A - rat
----------------------------MDVFSFGQG-----------------------
------N-------------N-----TTASQ------------EPFG-TGGNVTSIS---
-------DVT---------------FSYQ--------VITSLLLGTLIFCAVLGNACVVA
AIALERSLQNVANYLIGSLAVTDLMVSVLV-LPMAALYQVL-NKWT--LGQVTCDLFIAL
DVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLI-SIPPMLG
-WRT--PEDR---SDPDA-----CTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAAR
FRIRK----TVR---KVEKKG------------AGTSLGTSSA-----------------
---PP--P--KKS----------------LNGQPGSGDW-RR----CAENRAVGTPCTNG
AVRQGDDEATLEVIEVHRVGNSKE----HLPLP-SESGSNSYAPACLERKNERNAEA-KR
KMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPF-CESSC-HMPALLGAIINWLGYS
NSLLNPVIYAYFNKDFQNAFKK-----IIKC------KFC--------------------
-----------------------------RR-----------------------------
---------------------------------------------
>    34== L06803   1 Lymnaea stagnalis serotonin receptor <>[PNAS90,11-15'93]
-------------MANFTFGDLALDVARMGGLASTPSGLRS---------TGLTTPGLSP
TGLVTSDFNDSY-GLTGQFIN-----GSHSS------------RSRDNASANDTSAT---
-------NMTD------DRYWSLTVYSHE------HLVLTSVILGLFVLCCIIGNCFVIA
AVMLERSLHNVANYLILSLAVADLMVAVLV-MPLSVVSEIS-KVWF--LHSEVCDMWISV
DVLCCTASILHLVAIAMDRYWAVTS-IDYIRRRSARRILLMIMVVWIVALFI-SIPPLFG
-WRD--PNN-----DPDKTGT--CIISQDKGYTIFSTVGAFYLPMLVMMIIYIRIWLVAR
SRIRKDKFQMTKARLKTEETTLVASPKTEYSVVSDCNGCNSPD--STTEKKKRRAPFKSY
GCSPR--PERKKNRAKKLPEN-----ANGVNSNSSSSERLKQIQIETAEA------FANG
CA----EEASIAMLERQ-CNNGKKISSNDTP---YS-------------RTREKLEL-K-
-----RERKAARTLAIITGAFLICWLPFFIIALIGPF-VDPEG--IPPFARSFVLWLGYF
NSLLNPIIYTIFSPEFRSAFQK-----ILFG------KYR--------------------
-----------------------------RGHR---------------------------
---------------------------------------------
>    35=p A47174 serotonin receptor, 5HTlym receptor - great pond snail
-------------MANFTFGDLALDVARMGGLASTPSGLRS---------TGLTTPGLSP
TGLVTSDFNDSY-GLTGQFIN-----GSHSS------------RSRDNASANDTSAT---
-------NMTD------DRYWSLTVYSHE------HLVLTSVILGLFVLCCIIGNCFVIA
AVMLERSLHNVANYLILSLAVADLMVAVLV-MPLSVVSEIS-KVWF--LHSEVCDMWISV
DVLCCTASILHLVAIAMDRYWAVTS-IDYIRRRSARRILLMIMVVWIVALFI-SIPPLFG
-WRD--PNN-----DPDKTGT--CIISQDKGYTIFSTVGAFYLPMLVMMIIYIRIWLVAR
SRIRKDKFQMTKARLKTEETTLVASPKTEYSVVSDCNGCNSPD--STTEKKKRRAPFKSY
GCSPR--PERKKNRAKKLPEN-----ANGVNSNSSSSERLKQIQIETAEA------FANG
CA----EEASIAMLERQ-CNNGKKISSNDTP---YS-------------RTREKLEL-K-
-----RERKAARTLAIITGAFLICWLPFFIIALIGPF-VDPEG--IPPFARSFVLWLGYF
NSLLNPIIYTIFSPEFRSAFQK-----ILFG------KYR--------------------
-----------------------------RGHR---------------------------
---------------------------------------------
>    36== X95604   1 Bombyx mori serotonin receptor <antennae>[InsectBiochem.Mol.Bi
----------------------------MEG-AEGQEEL---------------------
------DWEALYLRLPLQ--N-----CSWNS------------TGWE-PNWNVTVVP---
-------NTT----------WWQASAPFDTPAALVRAAAKAVVLGLLILATVVGNVFVIA
AILLERHLRSAANNLILSLAVADLLVACLV-MPLGAVYEVV-QRWT--LGPELCDMWTSG
DVLCCTASILHLVAIALDRYWAVTN-IDYIHASTAKRVGMMIACVWTVSFFV-CIAQLLG
-WKD--PDW-----NQRVSEDLRCVVSQDVGYQIFATASSFYVPVLIILILYWRIYQTAR
KRIRRRRGATAR-----GGVGPPPVPAGGALVAGGGSGGIAAAVVAVIGR----------
---PL--PT--------ISETTTTGFTN-VSSNNTSPEK---------QS------CANG
-------------LEA------------DPPTTGYGAVAAAYYPSLVRRKPKEAADS-K-
-----RERKAAKTLAIITGAFVACWLPFFVLAILVPT-CDCEV--SPVLT-SLSLWLGYF
NSTLNPVIYTVFSPEFRHAFQR-----LLCG------RRV--------------------
-----------------------------RRRRA--------------------------
------------------PQ-------------------------
