>     1== M63632   1 Lampetra japonica rhodopsin <>[BBRC174,1125-1132'91]
MN----------------------------------------------------------
----GTEG--DNFY------------VPFSNKTG----------------------LARS
PYEYPQY------YLAEPWKYSALAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYIL
LNLAMANLFMVLFG-FTVTMYTSMN-GYFV--FGPTMCSIEGFFATLGGEVALWSLVVLA
IERYIVICKPMGNF-RFGNTHAIMGVAFTWIMALAC-AAPPLVG-WS-----RYIPEGMQ
CSCGPDYYTLNPNFNNESYVVYMFVVHFLVPFVIIFFCYGRLLCTVKEAAAAQQESA---
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------STQKAEKEVTRMVVLMVIGFLVCWV
PYASVAFYIFT---HQGSD-FGATFMTLPAFFAKSSALYNPVIYILMNKQFRNCMITTLC
C---GKNPLGDDE-SGA-STSKTEVSSVS-TSPV--------------------------
------------------------------------------------------------
-----------SPA---
>     2== U22180   1 rat opsin <rod>[J.Mol.Neurosci.5(3),207-209'94]
MN----------------------------------------------------------
----GTEG--PNFY------------VPFSNITG----------------------VVRS
PFEQPQY------YLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYIL
LNLAVADLFMVFGG-FTTTLYTSLH-GYFV--FGPTGCNLEGFFATLGGEIGLWSLVVLA
IERYVVVCKPMSNF-RFGENHAIMGVAFTWVMALAC-AAPPLVG-WS-----RYIPEGMQ
CSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIVIFFCYGQLVFTVKEAAAQQQESA---
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------TTQKAEKEVTRMVIIMVIFFLICWL
PYASVAMYIFT---HQGSN-FGPIFMTLPAFFAKTASIYNPIIYIMMNKQFRNCMLTSLC
C---GKNPLGDDE-ASA-TASKTE------TSQV--------------------------
------------------------------------------------------------
-----------APA---
>     3== M92038   1 chicken green sensitive cone opsin <retina>[PNAS89,5932-5936'9
MN----------------------------------------------------------
----GTEG--INFY------------VPMSNKTG----------------------VVRS
PFEYPQY------YLAEPWKYRLVCCYIFFLISTGLPINLLTLLVTFKHKKLRQPLNYIL
VNLAVADLFMACFG-FTVTFYTAWN-GYFV--FGPVGCAVEGFFATLGGQVALWSLVVLA
IERYIVVCKPMGNF-RFSATHAMMGIAFTWVMAFSC-AAPPLFG-WS-----RYMPEGMQ
CSCGPDYYTHNPDYHNESYVLYMFVIHFIIPVVVIFFSYGRLICKVREAAAQQQESA---
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------TTQKAEKEVTRMVILMVLGFMLAWT
PYAVVAFWIFT---NKGAD-FTATLMAVPAFFSKSSSLYNPIIYVLMNKQFRNCMITTIC
C---GKNPFGDEDVSSTVSQSKTEVSSVS-SSQV--------------------------
------------------------------------------------------------
-----------SPA---
>     4=p A45229 opsin, green-sensitive (clone GFgr-1) - goldfish
MN----------------------------------------------------------
----GTEG--KNFY------------VPMSNRTG----------------------LVRS
PFEYPQY------YLAEPWQFKILALYLFFLMSMGLPINGLTLVVTAQHKKLRQPLNFIL
VNLAVAGTIMVCFG-FTVTFYTAIN-GYFV--LGPTGCAVEGFMATLGGEVALWSLVVLA
IERYIVVCKPMGSF-KFSSSHAFAGIAFTWVMALAC-AAPPLFG-WS-----RYIPEGMQ
CSCGPDYYTLNPDYNNESYVIYMFVCHFILPVAVIFFTYGRLVCTVKAAAAQQQDSA---
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------STQKAEREVTKMVILMVFGFLIAWT
PYATVAAWIFF---NKGAD-FSAKFMAIPAFFSKSSALYNPVIYVLLNKQFRNCMLTTIF
C---GKNPLGDDE-SSTVSTSKTEVSS------V--------------------------
------------------------------------------------------------
-----------SPA---
>     5=p B45229 opsin, green-sensitive (clone GFgr-2) - goldfish
MN----------------------------------------------------------
----GTEG--NNFY------------VPLSNRTG----------------------LVRS
PFEYPQY------YLAEPWQFKLLAVYMFFLICLGLPINGLTLICTAQHKKLRQPLNFIL
VNLAVAGAIMVCFG-FTVTFYTAIN-GYFA--LGPTGCAVEGFMATLGGEVALWSLVVLA
IERYIVVCKPMGSF-KFSSTHASAGIAFTWVMAMAC-AAPPLVG-WS-----RYIPEGIQ
CSCGPDYYTLNPEYNNESYVLYMFICHFILPVTIIFFTYGRLVCTVKAAAAQQQDSA---
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------STQKAEREVTKMVILMVLGFLVAWT
PYATVAAWIFF---NKGAA-FSAQFMAIPAFFSKTSALYNPVIYVLLNKQFRSCMLTTLF
C---GKNPLGDEE-SSTVSTSKTEVSS------V--------------------------
------------------------------------------------------------
-----------SPA---
>     6== L11864   1 Carassius auratus blue cone opsin <retina>[Biochemistry32,208-
MK----------------------------------------------------------
----QVPEFHEDFY------IPIP--LDINNLSA------------------------YS
PFLVPQD------HLGNQGIFMAMSVFMFFIFIGGASINILTILCTIQFKKLRSHLNYIL
VNLSIANLFVAIFG-SPLSFYSFFN-RYFI--FGATACKIEGFLATLGGMVGLWSLAVVA
FERWLVICKPLGNF-TFKTPHAIAGCILPWISALAA-SLPPLFG-WS-----RYIPEGLQ
CSCGPDWYTTNNKYNNESYVMFLFCFCFAVPFGTIVFCYGQLLITLKLAAKAQADSA---
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------STQKAEREVTKMVVVMVLGFLVCWA
PYASFSLWIVS---HRGEE-FDLRMATIPSCLSKASTVYNPVIYVLMNKQFRSCMMKMVC
----GKN-IEEDE-AST-SSQVTQVSSVA-PEK---------------------------
------------------------------------------------------------
-----------------
>     7== M13299   1 human BCP <>[Science232(4747),193-202'86]
MR----------------------------------------------------------
----KMSE--EEFY------------L-FKNISS----------------------V--G
PWDGPQY------HIAPVWAFYLQAAFMGTVFLIGFPLNAMVLVATLRYKKLRQPLNYIL
VNVSFGGFLLCIFS-VFPVFVASCN-GYFV--FGRHVCALEGFLGTVAGLVTGWSLAFLA
FERYIVICKPFGNF-RFSSKHALTVVLATWTIGIGV-SIPPFFG-WS-----RFIPEGLQ
CSCGPDWYTVGTKYRSESYTWFLFIFCFIVPLSLICFSYTQLLRALKAVAAQQQESA---
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------TTQKAEREVSRMVVVMVGSFCVCYV
PYAAFAMYMVN---NRNHG-LDLRLVTIPSFFSKSACIYNPIIYCFMNKQFQACIMKMVC
----GKA-MTDES-DTC-SSQKTEVSTVS-STQV--------------------------
------------------------------------------------------------
-----------GPN---
>     8=opsin, greensensitive  human (fragment) S07060
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------DLAETVIA-STISIVNQVS-GYFV--LGHPMCVLEGYTVSLCGITGLWSLAIIS
WERWLVVCKPFGNV-RFDAKLAIVGIAFSWIWAAVW-TAPPIFG-WS-----RYWPHGLK
TSCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAIRAVAKQQKESE---
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------STQKAEKEVTRMVVVMVLAFC----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------
>     9== K03494   1 human GCP <>[Science232(4747),193-202'86]
MA------QQWS-LQRLAGRHPQDS--------------------------YED------
----STQS--SIFT------------YTNSNSTR-------------------------G
PFEGPNY------HIAPRWVYHLTSVWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWIL
VNLAVADLAETVIA-STISVVNQVY-GYFV--LGHPMCVLEGYTVSLCGITGLWSLAIIS
WERWMVVCKPFGNV-RFDAKLAIVGIAFSWIWAAVW-TAPPIFG-WS-----RYWPHGLK
TSCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAIRAVAKQQKESE---
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------STQKAEKEVTRMVVVMVLAFCFCWG
PYAFFACFAAA---NPGYP-FHPLMAALPAFFAKSATIYNPVIYVFMNRQFRNCILQLF-
----GKK-VDDGS-ELS-SASKTEVSSV---SSV--------------------------
------------------------------------------------------------
-----------SPA---
>    10== Z68193   1 human Red Opsin <>[]
MA------QQWS-LQRLAGRHPQDS--------------------------YED------
----STQS--SIFT------------YTNSNSTR-------------------------G
PFEGPNY------HIAPRWVYHLTSVWMIFVVTASVFTNGLVLAATMKFKKLRHPLNWIL
VNLAVADLAETVIA-STISIVNQVS-GYFV--LGHPMCVLEGYTVSLCGITGLWSLAIIS
WERWLVVCKPFGNV-RFDAKLAIVGIAFSWIWSAVW-TAPPIFG-WS-----RYWPHGLK
TSCGPDVFSGSSYPGVQSYMIVLMVTCCIIPLAIIMLCYLQVWLAIRAVAKQQKESE---
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------STQKAEKEVTRMVVVMIFAYCVCWG
PYTFFACFAAA---NPGYA-FHPLMAALPAYFAKSATIYNPVIYVFMNRQFRNCILQLF-
----GKK-VDDGS-ELS-SASKTEVSSV---SSV--------------------------
------------------------------------------------------------
-----------SPA---
>    11== M92036   1 Gecko gecko P521 <retina>[PNAS89,6841-6845'92]
MT------EAWNVAVFAARRSRDD----------------------------DD------
----TTRG--SVFT------------YTNTNNTR-------------------------G
PFEGPNY------HIAPRWVYNLVSFFMIIVVIASCFTNGLVLVATAKFKKLRHPLNWIL
VNLAFVDLVETLVA-STISVFNQIF-GYFI--LGHPLCVIEGYVVSSCGITGLWSLAIIS
WERWFVVCKPFGNI-KFDSKLAIIGIVFSWVWAWGW-SAPPIFG-WS-----RYWPHGLK
TSCGPDVFSGSVELGCQSFMLTLMITCCFLPLFIIIVCYLQVWMAIRAVAAQQKESE---
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------STQKAEREVSRMVVVMIVAFCICWG
PYASFVSFAAA---NPGYA-FHPLAAALPAYFAKSATIYNPVIYVFMNRQFRNCIMQLF-
----GKK-VDDGS-EAS-TTSRTEVSSVS-NSSV--------------------------
------------------------------------------------------------
-----------APA---
>    12== M62903   1 chicken visual pigment <>[BBRC173,1212-1217'90]
MA-------AWE-AAFAARRRHEE----------------------------ED------
----TTRD--SVFT------------YTNSNNTR-------------------------G
PFEGPNY------HIAPRWVYNLTSVWMIFVVAASVFTNGLVLVATWKFKKLRHPLNWIL
VNLAVADLGETVIA-STISVINQIS-GYFI--LGHPMCVVEGYTVSACGITALWSLAIIS
WERWFVVCKPFGNI-KFDGKLAVAGILFSWLWSCAW-TAPPIFG-WS-----RYWPHGLK
TSCGPDVFSGSSDPGVQSYMVVLMVTCCFFPLAIIILCYLQVWLAIRAVAAQQKESE---
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------STQKAEKEVSRMVVVMIVAYCFCWG
PYTFFACFAAA---NPGYA-FHPLAAALPAYFAKSATIYNPIIYVFMNRQFRNCILQLF-
----GKK-VDDGS-EVS--TSRTEVSSVS-NSSV--------------------------
------------------------------------------------------------
-----------SPA---
>    13== S75720   1 chicken P-opsin <>[Science267(5203),1502-1506'95]
MS----------------------------------------------------------
----SNSS------------------QAPPNGTP-------------------------G
PFDGPQWP-----YQAPQSTYVGVAVLMGTVVACASVVNGLVIVVSICYKKLRSPLNYIL
VNLAVADLLVTLCG-SSVSLSNNIN-GFFV--FGRRMCELEGFMVSLTGIVGLWSLAILA
LERYVVVCKPLGDF-QFQRRHAVSGCAFTWGWALLW-SAPPLLG-WS-----SYVPEGLR
TSCGPNWYTGGS--NNNSYILSLFVTCFVLPLSLILFSYTNLLLTLRAAAAQQKEAD---
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------TTQRAEREVTRMVIVMVMAFLLCWL
PYSTFALVVAT---HKGII-IQPVLASLPSYFSKTATVYNPIIYVFMNKQFQSCLLEMLC
C---GYQPQRTGKASPGTPGPHADVTAAGLRNKV--------------------------
------------------------------------------------------------
-----------MPAHPV
>    14== M17718   1 D.melanogaster Rh3 <>[J.Neurosci.7,1550-1557'87]
MESGNVS-----------------------------------------------------
SSLFGNVS--TALR-------------PEARLSA---E------TRLLGWNVPPEELRHI
PEHWLTY------PEPPESMNYLLGTLYIFFTLMSMLGNGLVIWVFSAAKSLRTPSNILV
INLAFCDFMMMVK--TPIFIYNSFH-QGYA--LGHLGCQIFGIIGSYTGIAAGATNAFIA
YDRFNVITRPMEG--KMTHGKAIAMIIFIYMYATPW-VVACYTETWG-----RFVPEGYL
TSCTFDYLTDN--FDTRLFVACIFFFSFVCPTTMITYYYSQIVGHVFSHEKALRDQAKKM
NVE------------------SLRS-----------------------------------
------------------------------------------------------------
-------------------------------NVDKNKETAEIRIAKAAITICFLFFCSWT
PYGVMSLIGAF---GDKTL-LTPGATMIPACACKMVACIDPFVYAISHPRYRMELQKRCP
WL--ALNEKAPES-SAV-ASTST---TQE-PQQT--------------------------
------------------------------------------------------------
-----------TAA---
>    15== X65879   1 Drosophila pseudoobscura Dpse\Rh3 <>[Genetics132(1),193-204'92
MEYHNVS-----------------------------------------------------
SVL-GNVS--SVLR-------------PDARLSA---E------SRLLGWNVPPDELRHI
PEHWLIY------PEPPESMNYLLGTLYIFFTVISMIGNGLVMWVFSAAKSLRTPSNILV
INLAFCDFMMMIK--TPIFIYNSFH-QGYA--LGHLGCQIFGVIGSYTGIAAGATNAFIA
YDRYNVITRPMEG--KMTHGKAIAMIIFIYLYATPW-VVACYTESWG-----RFVPEGYL
TSCTFDYLTDN--FDTRLFVACIFFFSFVCPTTMITYYYSQIVGHVFSHEKALRDQAKKM
NVD------------------SLRS-----------------------------------
------------------------------------------------------------
-------------------------------NVDKSKEAAEIRIAKAAITICFLFFASWT
PYGVMSLIGAF---GDKTL-LTPGATMIPACTCKMVACIDPFVYAISHPRYRMELQKRCP
WL--AISEKAPES-RAA-ISTST---TQE-QQQT--------------------------
------------------------------------------------------------
-----------TAA---
>    16== M17730   1 D.melanogaster Rh4 opsin <>[J.Neurosci.7,1558-1566'87]
ME----------------------------------------------------------
-PLCNASE--PPLR-------------PEAR-SSGNGD------LQFLGWNVPPDQIQYI
PEHWLTQ------LEPPASMHYMLGVFYIFLFCASTVGNGMVIWIFSTSKSLRTPSNMFV
LNLAVFDLIMCLK--APIF--NSFH-RGFAIYLGNTWCQIFASIGSYSGIGAGMTNAAIG
YDRYNVITKPMNR--NMTFTKAVIMNIIIWLYCTPW-VVLPLTQFWD-----RFVPEGYL
TSCSFDYLSDN--FDTRLFVGTIFFFSFVCPTLMILYYYSQIVGHVFSHEKALREQAKKM
NVE------------------SLRS-----------------------------------
------------------------------------------------------------
-------------------------------NVDKSKETAEIRIAKAAITICFLFFVSWT
PYGVMSLIGAF---GDKSL-LTQGATMIPACTCKLVACIDPFVYAISHPRYRLELQKRCP
WL--GVNEKSGEI-SSA-QSTTT---QEQ--QQT--------------------------
------------------------------------------------------------
-----------TAA---
>    17== X65880   1 Drosophila pseudoobscura Dpse\Rh4 <>[Genetics132(1),193-204'92
MD----------------------------------------------------------
-ALCNASE--PPLR-------------PEARMSSGSDE------LQFLGWNVPPDQIQYI
PEHWLTQ------LEPPASMHYMLGVFYIFLFFASTLGNGMVIWIFSTSKSLRTPSNMFV
LNLAVFDLIMCLK--APIFIYNSFH-RGFA--LGNTWCQIFASIGSYSGIGAGMTNAAIG
YDRYNVITKPMNR--NMTFTKAVIMNIIIWLYCTPW-VVLPLTQFWD-----RFVPEGYL
TSCSFDYLSDN--FDTRLFVGTIFLFSFVVPTLMILYYYSQIVGHVFNHEKALREQAKKM
NVE------------------SLRS-----------------------------------
------------------------------------------------------------
-------------------------------NVDKSKETAEIRIAKAAITICFLFFVSWT
PYGVMSLIGAF---GDKSL-LTPGATMIPACTCKLVACIEPFVYAISHPRYRMELQKRCP
WL--GVNEKSGEA-SSA-QSTTT---QEQ-TQQT--------------------------
------------------------------------------------------------
-----------SAA---
>    18== D50584   1 Hemigrapsus sanguineus opsin BcRh2 <compound eye>[J.Exp.Biol.1
MT----------------------------------------------------------
----NATG--PQMAY-----------YGAASMDFGYPE------GVSIVDFVRPEIKPYV
HQHWYNY------PPVNPMWHYLLGVIYLFLGTVSIFGNGLVIYLFNKSAALRTPANILV
VNLALSDLIMLTTN-VPFFTYNCFSGGVWM--FSPQYCEIYACLGAITGVCSIWLLCMIS
FDRYNIICNGFNGP-KLTTGKAVVFALISWVIAIGC-ALPPFFG-WG-----NYILEGIL
DSCSYDYLTQD--FNTFSYNIFIFVFDYFLPAAIIVFSYVFIVKAIFAHEAAMRAQAKKM
NVS------------------TLRS-----------------------------------
------------------------------------------------------------
--------------------------------NEADAQRAEIRIAKTALVNVSLWFICWT
PYALISLKGVM---GDTSG-ITPLVSTLPALLAKSCSCYNPFVYAISHPKYRLAITQHLP
WF--CVHETETKS-NDD-SQSNS---TVA-Q-----------------------------
------------------------------------------------------------
-----------DKA---
>    19== D50583   1 Hemigrapsus sanguineus opsin BcRh1 <compound eye>[J.Exp.Biol.1
MA----------------------------------------------------------
----NVTG--PQMAF-----------YGSGAATFGYPE------GMTVADFVPDRVKHMV
LDHWYNY------PPVNPMWHYLLGVVYLFLGVISIAGNGLVIYLYMKSQALKTPANMLI
VNLALSDLIMLTTN-FPPFCYNCFSGGRWM--FSGTYCEIYAALGAITGVCSIWTLCMIS
FDRYNIICNGFNGP-KLTQGKATFMCGLAWVISVGW-SLPPFFG-WG-----SYTLEGIL
DSCSYDYFTRD--MNTITYNICIFIFDFFLPASVIVFSYVFIVKAIFAHEAAMRAQAKKM
NVT------------------NLRS-----------------------------------
------------------------------------------------------------
--------------------------------NEAETQRAEIRIAKTALVNVSLWFICWT
PYAAITIQGLL---GNAEG-ITPLLTTLPALLAKSCSCYNPFVYAISHPKFRLAITQHLP
WF--CVHEKDPND-VEE-NQSSN---TQT-Q-----------------------------
------------------------------------------------------------
-----------EKS---
>    20== K02320   1 D.melanogaster opsin <>[Cell40,851-858'85]
MESF--------------------------------------------------------
AVAAAQLG--PHFA----------------PLS-----------NGSVVDKVTPDMAHLI
SPYWNQF------PAMDPIWAKILTAYMIMIGMISWCGNGVVIYIFATTKSLRTPANLLV
INLAISDFGIMITN-TPMMGINLYF-ETWV--LGPMMCDIYAGLGSAFGCSSIWSMCMIS
LDRYQVIVKGMAGR-PMTIPLALGKM---------------------------YVPEGNL
TSCGIDYLERD--WNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKAMREQAKKM
NVK------------------SLRS-----------------------------------
------------------------------------------------------------
--------------------------------SEDAEKSAEGKLAKVALVTITLWFMAWT
PYLVINCMGLF---KF-EG-LTPLNTIWGACFAKSAACYNPIVYGISHPKYRLALKEKCP
CC--VFGKVDDGK-SSD-AQSQA-TASEA-E-----------------------------
------------------------------------------------------------
-----------SKA---
>    21== K02315   1 D.melanogaster ninaE <>[Cell40,839-850'85]
MESF--------------------------------------------------------
AVAAAQLG--PHFA----------------PLS-----------NGSVVDKVTPDMAHLI
SPYWNQF------PAMDPIWAKILTAYMIMIGMISWCGNGVVIYIFATTKSLRTPANLLV
INLAISDFGIMITN-TPMMGINLYF-ETWV--LGPMMCDIYAGLGSAFGCSSIWSMCMIS
LDRYQVIVKGMAGR-PMTIPLALGKIAYIWFMSSIW-CLAPAFG-WS-----RYVPEGNL
TSCGIDYLERD--WNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKAMREQAKKM
NVK------------------SLRS-----------------------------------
------------------------------------------------------------
--------------------------------SEDAEKSAEGKLAKVALVTITLWFMAWT
PYLVINCMGLF---KF-EG-LTPLNTIWGACFAKSAACYNPIVYGISHPKYRLALKEKCP
CC--VFGKVDDGK-SSD-AQSQA-TASEA-E-----------------------------
------------------------------------------------------------
-----------SKA---
>    22== X65877   1 Drosophila pseudoobscura Dpse\ninaE <>[Genetics132(1),193-204'
MDSF--------------------------------------------------------
AAVATQLG--PQFA----------------APS-----------NGSVVDKVTPDMAHLI
SPYWDQF------PAMDPIWAKILTAYMIIIGMISWCGNGVVIYIFATTKSLRTPANLLV
INLAISDFGIMITN-TPMMGINLYF-ETWV--LGPMMCDIYAGLGSAFGCSSIWSMCMIS
LDRYQVIVKGMAGR-PMTIPLALGKIAYIWFMSTIWCCLAPVFG-WS-----RYVPEGNL
TSCGIDYLERD--WNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKAMREQAKKM
NVK------------------SLRS-----------------------------------
------------------------------------------------------------
--------------------------------SEDADKSAEGKLAKVALVTISLWFMAWT
PYLVINCMGLF---KF-EG-LTPLNTIWGACFAKSAACYNPIVYGISHPKYRLALKEKCP
CC--VFGKVDDGK-SSE-AQSQA-TTSEA-E-----------------------------
------------------------------------------------------------
-----------SKA---
>    23== M12896   1 D.melanogaster Rh2 <>[Cell44,705-710'86]
MERSHLP---------------------------------------------------ET
PFDLAHSG--PRFQ----------------AQSSG---------NGSVLDNVLPDMAHLV
NPYWSRF------APMDPMMSKILGLFTLAIMIISCCGNGVVVYIFGGTKSLRTPANLLV
LNLAFSDFCMMASQ-SPVMIINFYY-ETWV--LGPLWCDIYAGCGSLFGCVSIWSMCMIA
FDRYNVIVKGINGT-PMTIKTSIMKILFIWMMAVFW-TVMPLIG-WS-----AYVPEGNL
TACSIDYMTRM--WNPRSYLITYSLFVYYTPLFLICYSYWFIIAAVAAHEKAMREQAKKM
NVK------------------SLRS-----------------------------------
------------------------------------------------------------
--------------------------------SEDCDKSAEGKLAKVALTTISLWFMAWT
PYLVICYFGLF---KI-DG-LTPLTTIWGATFAKTSAVYNPIVYGISHPKYRIVLKEKCP
MC--VFGNTDEPK-PDA-PASDTETTSEA-D-----------------------------
------------------------------------------------------------
-----------SKA---
>    24== X65878   1 Drosophila pseudoobscura Dpse\Rh2 <>[Genetics132(1),193-204'92
MERSLLP---------------------------------------------------EP
PLAMALLG--PRFE----------------AQTGG---------NRSVLDNVLPDMAPLV
NPHWSRF------APMDPTMSKILGLFTLVILIISCCGNGVVVYIFGGTKSLRTPANLLV
LNLAFSDFCMMASQ-SPVMIINFYY-ETWV--LGPLWCDIYAACGSLFGCVSIWSMCMIA
FDRYNVIVKGINGT-PMTIKTSIMKIAFIWMMAVFW-TIMPLIG-WS-----SYVPEGNL
TACSIDYMTRQ--WNPRSYLITYSLFVYYTPLFMICYSYWFIIATVAAHEKAMRDQAKKM
NVK------------------SLRS-----------------------------------
------------------------------------------------------------
--------------------------------SEDCDKSAENKLAKVALTTISLWFMAWT
PYLIICYFGLF---KI-DG-LTPLTTIWGATFAKTSAVYNPIVYGISHPNDRLVLKEKCP
MC--VCGTTDEPK-PDA-PPSDTETTSEA-E-----------------------------
------------------------------------------------------------
-----------SKD---
>    25== U26026   1 Apis mellifera long-wavelength rhodopsin <>[]
MI----------------------------------------------------------
----AVSG--PSYE----------------AFSYGGQAR---FNNQTVVDKVPPDMLHLI
DANWYQY------PPLNPMWHGILGFVIGMLGFVSAMGNGMVVYIFLSTKSLRTPSNLFV
INLAISNFLMMFCM-SPPMVINCYY-ETWV--LGPLFCQIYAMLGSLFGCGSIWTMTMIA
FDRYNVIVKGLSGK-PLSINGALIRIIAIWLFSLGW-TIAPMFG-WN-----RYVPEGNM
TACGTDYFNRG--LLSASYLVCYGIWVYFVPLFLIIYSYWFIIQAVAAHEKNMREQAKKM
NVA------------------SLRS-----------------------------------
------------------------------------------------------------
--------------------------------SENQNTSAECKLAKVALMTISLWFMAWT
PYLVINFSGIF---NL-VK-ISPLFTIWGSLFAKANAVYNPIVYGISHPKYRAALFAKFP
SL--AC-AAEPSS-DAV-STTSG-TTTVT-DNEK--------------------------
------------------------------------------------------------
-----------SNA---
>    26== L03781   1 Limulus polyphemus opsin <>[PNAS90,6150-6154'93]
M-----------------------------------------------------------
-----ANQ--LSYS----------------SLGWPYQP------NASVVDTMPKEMLYMI
HEHWYAF------PPMNPLWYSILGVAMIILGIICVLGNGMVIYLMMTTKSLRTPTNLLV
VNLAFSDFCMMAFM-MPTMTSNCFA-ETWI--LGPFMCEVYGMAGSLFGCASIWSMVMIT
LDRYNVIVRGMAAA-PLTHKKATLLLLFVWIWSGGW-TILPFFG-WS-----RYVPEGNL
TSCTVDYLTKD--WSSASYVVIYGLAVYFLPLITMIYCYFFIVHAVAEHEKQLREQAKKM
NVA------------------SLRA-----------------------------------
------------------------------------------------------------
-------------------------------NADQQKQSAECRLAKVAMMTVGLWFMAWT
PYLIISWAGVF---SSGTR-LTPLATIWGSVFAKANSCYNPIVYGISHPRYKAALYQRFP
SL--ACGSGESGS-DVK-SEASA-TTTME-EKPK--------------------------
------------------------------------------------------------
----------IPEA---
>    27== X07797   1 Octopus dofleini rhodopsin <>[FEBS232(1),69-72'88]
MV----------------------------------------------------------
----ESTT--------------------LVNQTWWY--------NPTVD----------I
HPHWAKF------DPIPDAVYYSVGIFIGVVGIIGILGNGVVIYLFSKTKSLQTPANMFI
INLAMSDLSFSAINGFPLKTISAFM-KKWI--FGKVACQLYGLLGGIFGFMSINTMAMIS
IDRYNVIGRPMAASKKMSHRRAFLMIIFVWMWSIVW-SVGPVFN-WG-----AYVPEGIL
TSCSFDYLSTD--PSTRSFILCMYFCGFMLPIIIIAFCYFNIVMSVSNHEKEMAAMAKRL
NAK------------------ELRK-----------------------------------
------------------------------------------------------------
--------------------------------AQ-AGASAEMKLAKISMVIITQFMLSWS
PYAIIALLAQF---GPAEW-VTPYAAELPVLFAKASAIHNPIVYSVSHPKFREAIQTTFP
WLLTCCQFDEKEC-EDA-NDAEE---EVV-ASER--GGESRDAAQMKEMMAMMQKMQAQQ
AAYQP---PPPPQGYPPQGYPPQGAYPPPQGYPPQGYPPQGYPPQGYPPQGAPPQVEAPQ
GAPPQGVDNQAYQA---
>    28== X70498   1 Todarodes pacificus rhodopsin <retina>[FEBS317(1-2),5-11'93]
MG----------------------------------------------------------
----RDLR---------------------DNETWWY--------NPSIV----------V
HPHWREF------DQVPDAVYYSLGIFIGICGIIGCGGNGIVIYLFTKTKSLQTPANMFI
INLAFSDFTFSLVNGFPLMTISCFL-KKWI--FGFAACKVYGFIGGIFGFMSIMTMAMIS
IDRYNVIGRPMAASKKMSHRRAFIMIIFVWLWSVLW-AIGPIFG-WG-----AYTLEGVL
CNCSFDYISRD--STTRSNILCMFILGFFGPILIIFFCYFNIVMSVSNHEKEMAAMAKRL
NAK------------------ELRK-----------------------------------
------------------------------------------------------------
--------------------------------AQ-AGANAEMRLAKISIVIVSQFLLSWS
PYAVVALLAQF---GPLEW-VTPYAAQLPVMFAKASAIHNPMIYSVSHPKFREAISQTFP
WVLTCCQFDDKET-EDD-KDAET---EIP-AGESSDAAPSADAAQMKEMMAMMQKMQQQQ
AAYPPQGYAPPPQGYPPQGYPPQGY--PPQGYPPQGYPP---PPQGAPPQGAPP------
AAPPQGVDNQAYQA---
>    29== L21195   1 human serotonin 5-HT7 receptor protein <placenta and fetal bra
MMDVN-----------SSGRPDLYGHLRSFLLPEVGRGLPDLSPDG------------GA
DPVAGSWA--PHLL------------S---EVTASPAPTWDAPPDNASG-----------
---------CGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI
VSLALADLSVAVAV-MPFVSVTDLIGGKWI--FGHFFCNVFIAMDVMCCTASIMTLCVIS
IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASI-TLPPLFG-WA-----QNVNDDKV
CLISQDF----------GYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPG---
-----------FPRVEPDSVIALNG-----------------------------------
---------------------------IVKLQKE-------------------VEECAN-
-----------------LSRLLKH------ERKNISIFKREQKAATTLGIIVGAFTVCWL
PFFLLSTARPFICGTSCSC-IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQ
----CQYRNINRKLSAA-GMHEALKLAER-PERP-------------EFVL---------
------------------------------------------------------------
----QNADYCRKKGHDS
>    30== L15228   1 rat 5HT-7 serotonin receptor <>[JBC268,18200-18204'93]
M-----------------------------------------------------------
----------PHLL------------SGFLEVTASPAPTWDAPPDNVSG-----------
---------CGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVSFVKKLRQPSNYLI
VSLALADLSVAVAV-MPFVSVTDLIGGKWI--FGHFFCNVFIAMDVMCCTASIMTLCVIS
IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASI-TLPPLFG-WA-----QNVNDDKV
CLISQDF----------GYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPG---
-----------FPRVQPESVISLNG-----------------------------------
---------------------------VVKLQKE-------------------VEECAN-
-----------------LSRLLKH------ERKNISIFKREQKAATTLGIIVGAFTVCWL
PFFLLSTARPFICGTSCSC-IPLWVERTCLWLGYANSLINPFIYAFFNRDLRPTSRSLLQ
----CQYRNINRKLSAA-GMHEALKLAER-PERS-------------EFVL---------
------------------------------------------------------------
----QNSDHCGKKGHDT
>    31=p A47425 serotonin receptor 5HT-7 - rat
M-----------------------------------------------------------
----------PHLL------------SGFLEVTASPAPTWDAPPDNVSG-----------
---------CGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVSFVKKLRQPSNYLI
VSLALADLSVAVAV-MPFVSVTDLIGGKWI--FGHFFCNVFIAMDVMCCTASIMTLCVIS
IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASI-TLPPLFG-WA-----QNVNDDKV
CLISQDF----------GYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPG---
-----------FPRVQPESVISLNG-----------------------------------
---------------------------VVKLQKE-------------------VEECAN-
-----------------LSRLLKH------ERKNISIFKREQKAATTLGIIVGAFTVCWL
PFFLLSTARPFICGTSCSC-IPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQ
----CQYRNINRKLSAA-GMHEALKLAER-PERS-------------EFVL---------
------------------------------------------------------------
----QNSDHCGKKGHDT
>    32== M83181   1 human serotonin receptor <>[JBC267(11),7553-7562'92]
MDVLS-------------------------------------------------------
--------------------------PGQGNNTTSPPAPFETGGNTTGI-----------
-------------SDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLI
GSLAVTDLMVSVLV-LPMAALYQVL-NKWT--LGQVTCDLFIALDVLCCTSSILHLCAIA
LDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLI-SIPPMLG-WRTP---EDRSDPDA
CTISKDH----------GYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKT
GADTRHGASPAPQPKK-----SVNGE--SGSRNWRLGVESKAGGALC-------------
-----------------------------------ANGAVRQGDDGAALEVIEVHRVGNS
KEHLPLPSEAG--PTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWL
PFFIVALVLPF---CESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIK
----CKFCR---------------------------------------------------
------------------------------------------------------------
----------------Q
>    33=p A35181 serotonin receptor class 1A - rat
MDVFS-------------------------------------------------------
--------------------------FGQGNNTTASQEPFGTGGNVTSI-----------
-------------SDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLI
GSLAVTDLMVSVLV-LPMAALYQVL-NKWT--LGQVTCDLFIALDVLCCTSSILHLCAIA
LDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLI-SIPPMLG-WRTP---EDRSDPDA
CTISKDH----------GYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKK
GAGTSLGTSSAPPPKK-----SLNGQ--PGSGDWRRCAENRAVGTPC-------------
-----------------------------------TNGAVRQGDDEATLEVIEVHRVGNS
KEHLPLPSESG--SNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWL
PFFIVALVLPF---CESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIK
----CKFCR---------------------------------------------------
------------------------------------------------------------
----------------R
>    34== L06803   1 Lymnaea stagnalis serotonin receptor <>[PNAS90,11-15'93]
MANFTFGDLALD-VARMGGLASTPSGLRS-----TGLTTPGLSPTGLVTSDFNDSYGLTG
QFINGSHS--SRSRD-----------NASANDT-----------SATNM----------T
DDRYWSL------TVYSHEHLVLTSVILGLFVLCCIIGNCFVIAAVMLERSLHNVANYLI
LSLAVADLMVAVLV-MPLSVVSEIS-KVWF--LHSEVCDMWISVDVLCCTASILHLVAIA
MDRYWAVTS-IDYIRRRSARRILLMIMVVWIVALFI-SIPPLFG-WRDP--NNDPDKTGT
CIISQDK----------GYTIFSTVGAFYLPMLVMMIIYIRIWLVARSRIRKDKFQMTKA
RLKTEETTLVASPKTEYSVVSDCNGCNSPDSTTEKKKRRAPFKSYGCSPRPERKKNRAKK
LPENANGVNSNSSS----------SERLKQIQIETAEAFANGCAEEASIAML-ERQCNNG
KK-------------------ISSNDTPYSRTREKLELKRERKAARTLAIITGAFLICWL
PFFIIALIGPF---VDPEG-IPPFARSFVLWLGYFNSLLNPIIYTIFSPEFRSAFQKILF
----GKYRRGH-------------------------------------------------
------------------------------------------------------------
----------------R
>    35=p A47174 serotonin receptor, 5HTlym receptor - great pond snail
MANFTFGDLALD-VARMGGLASTPSGLRS-----TGLTTPGLSPTGLVTSDFNDSYGLTG
QFINGSHS--SRSRD-----------NASANDT-----------SATNM----------T
DDRYWSL------TVYSHEHLVLTSVILGLFVLCCIIGNCFVIAAVMLERSLHNVANYLI
LSLAVADLMVAVLV-MPLSVVSEIS-KVWF--LHSEVCDMWISVDVLCCTASILHLVAIA
MDRYWAVTS-IDYIRRRSARRILLMIMVVWIVALFI-SIPPLFG-WRDP--NNDPDKTGT
CIISQDK----------GYTIFSTVGAFYLPMLVMMIIYIRIWLVARSRIRKDKFQMTKA
RLKTEETTLVASPKTEYSVVSDCNGCNSPDSTTEKKKRRAPFKSYGCSPRPERKKNRAKK
LPENANGVNSNSSS----------SERLKQIQIETAEAFANGCAEEASIAML-ERQCNNG
KK-------------------ISSNDTPYSRTREKLELKRERKAARTLAIITGAFLICWL
PFFIIALIGPF---VDPEG-IPPFARSFVLWLGYFNSLLNPIIYTIFSPEFRSAFQKILF
----GKYRRGH-------------------------------------------------
------------------------------------------------------------
----------------R
>    36== X95604   1 Bombyx mori serotonin receptor <antennae>[InsectBiochem.Mol.Bi
ME----------------------------------------------------------
----GAEG--QEELDWEALYLRLPLQNCSWNSTGWEPN-----WNVTVV----------P
NTTWWQASAPFD-TPAALVRAAAKAVVLGLLILATVVGNVFVIAAILLERHLRSAANNLI
LSLAVADLLVACLV-MPLGAVYEVV-QRWT--LGPELCDMWTSGDVLCCTASILHLVAIA
LDRYWAVTN-IDYIHASTAKRVGMMIACVWTVSFFV-CIAQLLG-WKDPDWNQRVSEDLR
CVVSQDV----------GYQIFATASSFYVPVLIILILYWRIYQTARKRIRRRRGATARG
GVG---------------------------------------------PPP---------
VPAGGALVAGGGSGGIAAAVVAVIGRPLPTISETTTTGFTNVSSNNTSPE---KQSCANG
LEADPPTTGYGAVAAAYYPSLVRR------KPKEAADSKRERKAAKTLAIITGAFVACWL
PFFVLAILVPT---CDCE--VSPVLTSLSLWLGYFNSTLNPVIYTVFSPEFRHAFQRLLC
----GRRVRRRRA-----------------------------------------------
----P-------------------------------------------------------
----------------Q
