>     1== M63632   1 Lampetra japonica rhodopsin <>[BBRC174,1125-1132'91]
-------------------MNGTE-G------DNFYVPFSN---------KTGLARSPYE
YPQY-------------------------------------------------------Y
LAEPW--------------KYSALAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYIL
LNLAMANLFMVLFG-FTVTMYTSMN-GYFV--FGPTMCSIEGFFATLGGEVALWSLVVLA
IERYIVICKPMGNF-RFGNTHAIMGVAFTWIMALAC-AAPPLVG-WS-----RYIPEGMQ
CSCGPDYYTLNPNFNNESYVVYMFVVHFLVPFVIIFFCYGRLLCTVKEAAAAQQESA---
------------------------------------------------------------
------------------------------------------------------------
---------------------------STQKAEKEVTRMVVLMVIGFLVCWVPYASVAFY
IFT---HQGS-DFGATFMTLPAFFAKSSALYNPVIYILMNKQFRNCMITTL-----CC--
---GKNPLGDDE-SGA-STSK-TEVSSVS-TSPVSPA-----------------------
------------------------------------------------------------
-----------
>     2== U22180   1 rat opsin <rod>[J.Mol.Neurosci.5(3),207-209'94]
-------------------MNGTE-G------PNFYVPFSN---------ITGVVRSPFE
QPQY-------------------------------------------------------Y
LAEPW--------------QFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYIL
LNLAVADLFMVFGG-FTTTLYTSLH-GYFV--FGPTGCNLEGFFATLGGEIGLWSLVVLA
IERYVVVCKPMSNF-RFGENHAIMGVAFTWVMALAC-AAPPLVG-WS-----RYIPEGMQ
CSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIVIFFCYGQLVFTVKEAAAQQQESA---
------------------------------------------------------------
------------------------------------------------------------
---------------------------TTQKAEKEVTRMVIIMVIFFLICWLPYASVAMY
IFT---HQGS-NFGPIFMTLPAFFAKTASIYNPIIYIMMNKQFRNCMLTSL-----CC--
---GKNPLGDDE-ASA-TASK-TETSQVA-PA----------------------------
------------------------------------------------------------
-----------
>     3== M92038   1 chicken green sensitive cone opsin <retina>[PNAS89,5932-5936'9
-------------------MNGTE-G------INFYVPMSN---------KTGVVRSPFE
YPQY-------------------------------------------------------Y
LAEPW--------------KYRLVCCYIFFLISTGLPINLLTLLVTFKHKKLRQPLNYIL
VNLAVADLFMACFG-FTVTFYTAWN-GYFV--FGPVGCAVEGFFATLGGQVALWSLVVLA
IERYIVVCKPMGNF-RFSATHAMMGIAFTWVMAFSC-AAPPLFG-WS-----RYMPEGMQ
CSCGPDYYTHNPDYHNESYVLYMFVIHFIIPVVVIFFSYGRLICKVREAAAQQQESA---
------------------------------------------------------------
------------------------------------------------------------
---------------------------TTQKAEKEVTRMVILMVLGFMLAWTPYAVVAFW
IFT---NKGA-DFTATLMAVPAFFSKSSSLYNPIIYVLMNKQFRNCMITTI-----CC--
---GKNPFGDEDVSSTVSQSK-TEVSSVS-SSQVSPA-----------------------
------------------------------------------------------------
-----------
>     4=p A45229 opsin, green-sensitive (clone GFgr-1) - goldfish
-------------------MNGTE-G------KNFYVPMSN---------RTGLVRSPFE
YPQY-------------------------------------------------------Y
LAEPW--------------QFKILALYLFFLMSMGLPINGLTLVVTAQHKKLRQPLNFIL
VNLAVAGTIMVCFG-FTVTFYTAIN-GYFV--LGPTGCAVEGFMATLGGEVALWSLVVLA
IERYIVVCKPMGSF-KFSSSHAFAGIAFTWVMALAC-AAPPLFG-WS-----RYIPEGMQ
CSCGPDYYTLNPDYNNESYVIYMFVCHFILPVAVIFFTYGRLVCTVKAAAAQQQDSA---
------------------------------------------------------------
------------------------------------------------------------
---------------------------STQKAEREVTKMVILMVFGFLIAWTPYATVAAW
IFF---NKGA-DFSAKFMAIPAFFSKSSALYNPVIYVLLNKQFRNCMLTTI-----FC--
---GKNPLGDDE-SSTVSTSK-TEVSSVS-PA----------------------------
------------------------------------------------------------
-----------
>     5=p B45229 opsin, green-sensitive (clone GFgr-2) - goldfish
-------------------MNGTE-G------NNFYVPLSN---------RTGLVRSPFE
YPQY-------------------------------------------------------Y
LAEPW--------------QFKLLAVYMFFLICLGLPINGLTLICTAQHKKLRQPLNFIL
VNLAVAGAIMVCFG-FTVTFYTAIN-GYFA--LGPTGCAVEGFMATLGGEVALWSLVVLA
IERYIVVCKPMGSF-KFSSTHASAGIAFTWVMAMAC-AAPPLVG-WS-----RYIPEGIQ
CSCGPDYYTLNPEYNNESYVLYMFICHFILPVTIIFFTYGRLVCTVKAAAAQQQDSA---
------------------------------------------------------------
------------------------------------------------------------
---------------------------STQKAEREVTKMVILMVLGFLVAWTPYATVAAW
IFF---NKGA-AFSAQFMAIPAFFSKTSALYNPVIYVLLNKQFRSCMLTTL-----FC--
---GKNPLGDEE-SSTVSTSK-TEVSSVS-PA----------------------------
------------------------------------------------------------
-----------
>     6== L11864   1 Carassius auratus blue cone opsin <retina>[Biochemistry32,208-
-------------------MKQVP-EF----HEDFYIPIPL-------DINNLSAYSPFL
VPQD-------------------------------------------------------H
LGNQG--------------IFMAMSVFMFFIFIGGASINILTILCTIQFKKLRSHLNYIL
VNLSIANLFVAIFG-SPLSFYSFFN-RYFI--FGATACKIEGFLATLGGMVGLWSLAVVA
FERWLVICKPLGNF-TFKTPHAIAGCILPWISALAA-SLPPLFG-WS-----RYIPEGLQ
CSCGPDWYTTNNKYNNESYVMFLFCFCFAVPFGTIVFCYGQLLITLKLAAKAQADSA---
------------------------------------------------------------
------------------------------------------------------------
---------------------------STQKAEREVTKMVVVMVLGFLVCWAPYASFSLW
IVS---HRGE-EFDLRMATIPSCLSKASTVYNPVIYVLMNKQFRSCMMKMV-----C---
---GKN-IEEDE-AST-SSQV-TQVSSVA-PEK---------------------------
------------------------------------------------------------
-----------
>     7== M13299   1 human BCP <>[Science232(4747),193-202'86]
-------------------MRKMS-E------EEFYL------------FKNISSVGPWD
GPQY-------------------------------------------------------H
IAPVW--------------AFYLQAAFMGTVFLIGFPLNAMVLVATLRYKKLRQPLNYIL
VNVSFGGFLLCIFS-VFPVFVASCN-GYFV--FGRHVCALEGFLGTVAGLVTGWSLAFLA
FERYIVICKPFGNF-RFSSKHALTVVLATWTIGIGV-SIPPFFG-WS-----RFIPEGLQ
CSCGPDWYTVGTKYRSESYTWFLFIFCFIVPLSLICFSYTQLLRALKAVAAQQQESA---
------------------------------------------------------------
------------------------------------------------------------
---------------------------TTQKAEREVSRMVVVMVGSFCVCYVPYAAFAMY
MVN---NRNH-GLDLRLVTIPSFFSKSACIYNPIIYCFMNKQFQACIMKMV-----C---
---GKA-MTDES-DTC-SSQK-TEVSTVS-STQVGPN-----------------------
------------------------------------------------------------
-----------
>     8=opsin, greensensitive  human (fragment) S07060
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------DLAETVIA-STISIVNQVS-GYFV--LGHPMCVLEGYTVSLCGITGLWSLAIIS
WERWLVVCKPFGNV-RFDAKLAIVGIAFSWIWAAVW-TAPPIFG-WS-----RYWPHGLK
TSCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAIRAVAKQQKESE---
------------------------------------------------------------
------------------------------------------------------------
---------------------------STQKAEKEVTRMVVVMVLAFC------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------
>     9== K03494   1 human GCP <>[Science232(4747),193-202'86]
MAQQWSLQRLAGRHPQDSYEDSTQ-S------SIFTYTNSN------------STRGPFE
GPNY-------------------------------------------------------H
IAPRW--------------VYHLTSVWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWIL
VNLAVADLAETVIA-STISVVNQVY-GYFV--LGHPMCVLEGYTVSLCGITGLWSLAIIS
WERWMVVCKPFGNV-RFDAKLAIVGIAFSWIWAAVW-TAPPIFG-WS-----RYWPHGLK
TSCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAIRAVAKQQKESE---
------------------------------------------------------------
------------------------------------------------------------
---------------------------STQKAEKEVTRMVVVMVLAFCFCWGPYAFFACF
AAA---NPGY-PFHPLMAALPAFFAKSATIYNPVIYVFMNRQFRNCILQLF---------
---GKK-VDDGS-ELS-SASK-TEVSSVS---SVSPA-----------------------
------------------------------------------------------------
-----------
>    10== Z68193   1 human Red Opsin <>[]
MAQQWSLQRLAGRHPQDSYEDSTQ-S------SIFTYTNSN------------STRGPFE
GPNY-------------------------------------------------------H
IAPRW--------------VYHLTSVWMIFVVTASVFTNGLVLAATMKFKKLRHPLNWIL
VNLAVADLAETVIA-STISIVNQVS-GYFV--LGHPMCVLEGYTVSLCGITGLWSLAIIS
WERWLVVCKPFGNV-RFDAKLAIVGIAFSWIWSAVW-TAPPIFG-WS-----RYWPHGLK
TSCGPDVFSGSSYPGVQSYMIVLMVTCCIIPLAIIMLCYLQVWLAIRAVAKQQKESE---
------------------------------------------------------------
------------------------------------------------------------
---------------------------STQKAEKEVTRMVVVMIFAYCVCWGPYTFFACF
AAA---NPGY-AFHPLMAALPAYFAKSATIYNPVIYVFMNRQFRNCILQLF---------
---GKK-VDDGS-ELS-SASK-TEVSSVS---SVSPA-----------------------
------------------------------------------------------------
-----------
>    11== M92036   1 Gecko gecko P521 <retina>[PNAS89,6841-6845'92]
MTEAWNVAVFAARRSRDD-DDTTR-G------SVFTYTNTN------------NTRGPFE
GPNY-------------------------------------------------------H
IAPRW--------------VYNLVSFFMIIVVIASCFTNGLVLVATAKFKKLRHPLNWIL
VNLAFVDLVETLVA-STISVFNQIF-GYFI--LGHPLCVIEGYVVSSCGITGLWSLAIIS
WERWFVVCKPFGNI-KFDSKLAIIGIVFSWVWAWGW-SAPPIFG-WS-----RYWPHGLK
TSCGPDVFSGSVELGCQSFMLTLMITCCFLPLFIIIVCYLQVWMAIRAVAAQQKESE---
------------------------------------------------------------
------------------------------------------------------------
---------------------------STQKAEREVSRMVVVMIVAFCICWGPYASFVSF
AAA---NPGY-AFHPLAAALPAYFAKSATIYNPVIYVFMNRQFRNCIMQLF---------
---GKK-VDDGS-EAS-TTSR-TEVSSVS-NSSVAPA-----------------------
------------------------------------------------------------
-----------
>    12== M62903   1 chicken visual pigment <>[BBRC173,1212-1217'90]
MA-AWE-AAFAARRRHEE-EDTTR-D------SVFTYTNSN------------NTRGPFE
GPNY-------------------------------------------------------H
IAPRW--------------VYNLTSVWMIFVVAASVFTNGLVLVATWKFKKLRHPLNWIL
VNLAVADLGETVIA-STISVINQIS-GYFI--LGHPMCVVEGYTVSACGITALWSLAIIS
WERWFVVCKPFGNI-KFDGKLAVAGILFSWLWSCAW-TAPPIFG-WS-----RYWPHGLK
TSCGPDVFSGSSDPGVQSYMVVLMVTCCFFPLAIIILCYLQVWLAIRAVAAQQKESE---
------------------------------------------------------------
------------------------------------------------------------
---------------------------STQKAEKEVSRMVVVMIVAYCFCWGPYTFFACF
AAA---NPGY-AFHPLAAALPAYFAKSATIYNPIIYVFMNRQFRNCILQLF---------
---GKK-VDDGS-EVS-T-SR-TEVSSVS-NSSVSPA-----------------------
------------------------------------------------------------
-----------
>    13== S75720   1 chicken P-opsin <>[Science267(5203),1502-1506'95]
-----------------------M-S------SNSSQAPPN------------GTPGPFD
GPQW------------------------------------------------------PY
QAPQS--------------TYVGVAVLMGTVVACASVVNGLVIVVSICYKKLRSPLNYIL
VNLAVADLLVTLCG-SSVSLSNNIN-GFFV--FGRRMCELEGFMVSLTGIVGLWSLAILA
LERYVVVCKPLGDF-QFQRRHAVSGCAFTWGWALLW-SAPPLLG-WS-----SYVPEGLR
TSCGPNWYTGGSN--NNSYILSLFVTCFVLPLSLILFSYTNLLLTLRAAAAQQKEAD---
------------------------------------------------------------
------------------------------------------------------------
---------------------------TTQRAEREVTRMVIVMVMAFLLCWLPYSTFALV
VAT---HKGI-IIQPVLASLPSYFSKTATVYNPIIYVFMNKQFQSCLLEML-----CCGY
--QPQR-TGKAS-PGT-PGPH-ADVTAAGLRNKVMPAHPV--------------------
------------------------------------------------------------
-----------
>    14== M17718   1 D.melanogaster Rh3 <>[J.Neurosci.7,1550-1557'87]
-------------------MESGNVS------SSLF-----------------GNVSTAL
RPEA------------------------------RLSA---E---TRLLGWNVPPEELRH
IPEHWLTYP-----EPPESMNYLLGTLYIFFTLMSMLGNGLVIWVFSAAKSLRTPSNILV
INLAFCDFMMMVK--TPIFIYNSFH-QGYA--LGHLGCQIFGIIGSYTGIAAGATNAFIA
YDRFNVITRPMEG--KMTHGKAIAMIIFIYMYATPW-VVACYTETWG-----RFVPEGYL
TSCTFDYLTDN--FDTRLFVACIFFFSFVCPTTMITYYYSQIVGHVFSHEKALRDQAKKM
NVES--------------------------------------------------------
------------------------------------------------------------
-------------LRS-------NVDKNKETAEIRIAKAAITICFLFFCSWTPYGVMSLI
GAF---GDKT-LLTPGATMIPACACKMVACIDPFVYAISHPRYRMELQKRCPWL--AL--
---NEK-APESS-AVA-STST-TQEPQQT---------------------------TAA-
------------------------------------------------------------
-----------
>    15== X65879   1 Drosophila pseudoobscura Dpse\Rh3 <>[Genetics132(1),193-204'92
-------------------MEYHNVS------SVL------------------GNVSSVL
RPDA------------------------------RLSA---E---SRLLGWNVPPDELRH
IPEHWLIYP-----EPPESMNYLLGTLYIFFTVISMIGNGLVMWVFSAAKSLRTPSNILV
INLAFCDFMMMIK--TPIFIYNSFH-QGYA--LGHLGCQIFGVIGSYTGIAAGATNAFIA
YDRYNVITRPMEG--KMTHGKAIAMIIFIYLYATPW-VVACYTESWG-----RFVPEGYL
TSCTFDYLTDN--FDTRLFVACIFFFSFVCPTTMITYYYSQIVGHVFSHEKALRDQAKKM
NVDS--------------------------------------------------------
------------------------------------------------------------
-------------LRS-------NVDKSKEAAEIRIAKAAITICFLFFASWTPYGVMSLI
GAF---GDKT-LLTPGATMIPACTCKMVACIDPFVYAISHPRYRMELQKRCPWL--AI--
---SEK-APESR-AAI-STST-TQEQQQT---------------------------TAA-
------------------------------------------------------------
-----------
>    16== M17730   1 D.melanogaster Rh4 opsin <>[J.Neurosci.7,1558-1566'87]
-------------------MEPLC-----------------------------NASEPPL
RPEA------------------------------R-SSGNGD---LQFLGWNVPPDQIQY
IPEHWLTQL-----EPPASMHYMLGVFYIFLFCASTVGNGMVIWIFSTSKSLRTPSNMFV
LNLAVFDLIMCLK--APIF--NSFH-RGFAIYLGNTWCQIFASIGSYSGIGAGMTNAAIG
YDRYNVITKPMNR--NMTFTKAVIMNIIIWLYCTPW-VVLPLTQFWD-----RFVPEGYL
TSCSFDYLSDN--FDTRLFVGTIFFFSFVCPTLMILYYYSQIVGHVFSHEKALREQAKKM
NVES--------------------------------------------------------
------------------------------------------------------------
-------------LRS-------NVDKSKETAEIRIAKAAITICFLFFVSWTPYGVMSLI
GAF---GDKS-LLTQGATMIPACTCKLVACIDPFVYAISHPRYRLELQKRCPWL--GV--
---NEK-SGEIS-SAQ-STTT-QEQQQTT---------------------------AA--
------------------------------------------------------------
-----------
>    17== X65880   1 Drosophila pseudoobscura Dpse\Rh4 <>[Genetics132(1),193-204'92
-------------------MDALC-----------------------------NASEPPL
RPEA------------------------------RMSSGSDE---LQFLGWNVPPDQIQY
IPEHWLTQL-----EPPASMHYMLGVFYIFLFFASTLGNGMVIWIFSTSKSLRTPSNMFV
LNLAVFDLIMCLK--APIFIYNSFH-RGFA--LGNTWCQIFASIGSYSGIGAGMTNAAIG
YDRYNVITKPMNR--NMTFTKAVIMNIIIWLYCTPW-VVLPLTQFWD-----RFVPEGYL
TSCSFDYLSDN--FDTRLFVGTIFLFSFVVPTLMILYYYSQIVGHVFNHEKALREQAKKM
NVES--------------------------------------------------------
------------------------------------------------------------
-------------LRS-------NVDKSKETAEIRIAKAAITICFLFFVSWTPYGVMSLI
GAF---GDKS-LLTPGATMIPACTCKLVACIEPFVYAISHPRYRMELQKRCPWL--GV--
---NEK-SGEAS-SAQ-STTT-QEQTQQT---------------------------SAA-
------------------------------------------------------------
-----------
>    18== D50584   1 Hemigrapsus sanguineus opsin BcRh2 <compound eye>[J.Exp.Biol.1
-------------------------------------------------------MTNAT
GPQMAY-------YG-----------------AASMDFGYPE---GVSIVDFVRPEIKPY
VHQHWYNYP-----PVNPMWHYLLGVIYLFLGTVSIFGNGLVIYLFNKSAALRTPANILV
VNLALSDLIMLTTN-VPFFTYNCFSGGVWM--FSPQYCEIYACLGAITGVCSIWLLCMIS
FDRYNIICNGFNGP-KLTTGKAVVFALISWVIAIGC-ALPPFFG-WG-----NYILEGIL
DSCSYDYLTQD--FNTFSYNIFIFVFDYFLPAAIIVFSYVFIVKAIFAHEAAMRAQAKKM
NVST--------------------------------------------------------
------------------------------------------------------------
-------------LRS--------NEADAQRAEIRIAKTALVNVSLWFICWTPYALISLK
GVM---GDTS-GITPLVSTLPALLAKSCSCYNPFVYAISHPKYRLAITQHLPWF--CV--
---HET-ETKSN-DDS-QSNS-TVAQDKA-------------------------------
------------------------------------------------------------
-----------
>    19== D50583   1 Hemigrapsus sanguineus opsin BcRh1 <compound eye>[J.Exp.Biol.1
-------------------------------------------------------MANVT
GPQMAF-------YG-----------------SGAATFGYPE---GMTVADFVPDRVKHM
VLDHWYNYP-----PVNPMWHYLLGVVYLFLGVISIAGNGLVIYLYMKSQALKTPANMLI
VNLALSDLIMLTTN-FPPFCYNCFSGGRWM--FSGTYCEIYAALGAITGVCSIWTLCMIS
FDRYNIICNGFNGP-KLTQGKATFMCGLAWVISVGW-SLPPFFG-WG-----SYTLEGIL
DSCSYDYFTRD--MNTITYNICIFIFDFFLPASVIVFSYVFIVKAIFAHEAAMRAQAKKM
NVTN--------------------------------------------------------
------------------------------------------------------------
-------------LRS--------NEAETQRAEIRIAKTALVNVSLWFICWTPYAAITIQ
GLL---GNAE-GITPLLTTLPALLAKSCSCYNPFVYAISHPKFRLAITQHLPWF--CV--
---HEK-DPNDV-EEN-QSSN-TQTQEKS-------------------------------
------------------------------------------------------------
-----------
>    20== K02320   1 D.melanogaster opsin <>[Cell40,851-858'85]
-------------------MESFA------------------------------VAAAQL
GPHFA-----------------------------PLS--------NGSVVDKVTPDMAHL
ISPYWNQFP-----AMDPIWAKILTAYMIMIGMISWCGNGVVIYIFATTKSLRTPANLLV
INLAISDFGIMITN-TPMMGINLYF-ETWV--LGPMMCDIYAGLGSAFGCSSIWSMCMIS
LDRYQVIVKGMAGR-PMTIPLALGKM---------------------------YVPEGNL
TSCGIDYLERD--WNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKAMREQAKKM
NVKS--------------------------------------------------------
------------------------------------------------------------
-------------LRS--------SEDAEKSAEGKLAKVALVTITLWFMAWTPYLVINCM
GLF---KF-E-GLTPLNTIWGACFAKSAACYNPIVYGISHPKYRLALKEKCPCC--VF--
---GKV-DDGKS-SDA-QSQA-TASEAES------KA-----------------------
------------------------------------------------------------
-----------
>    21== K02315   1 D.melanogaster ninaE <>[Cell40,839-850'85]
-------------------MESFA------------------------------VAAAQL
GPHFA-----------------------------PLS--------NGSVVDKVTPDMAHL
ISPYWNQFP-----AMDPIWAKILTAYMIMIGMISWCGNGVVIYIFATTKSLRTPANLLV
INLAISDFGIMITN-TPMMGINLYF-ETWV--LGPMMCDIYAGLGSAFGCSSIWSMCMIS
LDRYQVIVKGMAGR-PMTIPLALGKIAYIWFMSSIW-CLAPAFG-WS-----RYVPEGNL
TSCGIDYLERD--WNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKAMREQAKKM
NVKS--------------------------------------------------------
------------------------------------------------------------
-------------LRS--------SEDAEKSAEGKLAKVALVTITLWFMAWTPYLVINCM
GLF---KF-E-GLTPLNTIWGACFAKSAACYNPIVYGISHPKYRLALKEKCPCC--VF--
---GKV-DDGKS-SDA-QSQA-TASEAES------KA-----------------------
------------------------------------------------------------
-----------
>    22== X65877   1 Drosophila pseudoobscura Dpse\ninaE <>[Genetics132(1),193-204'
-------------------MDSFA------------------------------AVATQL
GPQFA-----------------------------APS--------NGSVVDKVTPDMAHL
ISPYWDQFP-----AMDPIWAKILTAYMIIIGMISWCGNGVVIYIFATTKSLRTPANLLV
INLAISDFGIMITN-TPMMGINLYF-ETWV--LGPMMCDIYAGLGSAFGCSSIWSMCMIS
LDRYQVIVKGMAGR-PMTIPLALGKIAYIWFMSTIWCCLAPVFG-WS-----RYVPEGNL
TSCGIDYLERD--WNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKAMREQAKKM
NVKS--------------------------------------------------------
------------------------------------------------------------
-------------LRS--------SEDADKSAEGKLAKVALVTISLWFMAWTPYLVINCM
GLF---KF-E-GLTPLNTIWGACFAKSAACYNPIVYGISHPKYRLALKEKCPCC--VF--
---GKV-DDGKS-SEA-QSQA-TTSEAES------KA-----------------------
------------------------------------------------------------
-----------
>    23== M12896   1 D.melanogaster Rh2 <>[Cell44,705-710'86]
-------------------MERSH-------------------------LPETPFDLAHS
GPRFQ-----------------------------AQSSG------NGSVLDNVLPDMAHL
VNPYWSRFA-----PMDPMMSKILGLFTLAIMIISCCGNGVVVYIFGGTKSLRTPANLLV
LNLAFSDFCMMASQ-SPVMIINFYY-ETWV--LGPLWCDIYAGCGSLFGCVSIWSMCMIA
FDRYNVIVKGINGT-PMTIKTSIMKILFIWMMAVFW-TVMPLIG-WS-----AYVPEGNL
TACSIDYMTRM--WNPRSYLITYSLFVYYTPLFLICYSYWFIIAAVAAHEKAMREQAKKM
NVKS--------------------------------------------------------
------------------------------------------------------------
-------------LRS--------SEDCDKSAEGKLAKVALTTISLWFMAWTPYLVICYF
GLF---KI-D-GLTPLTTIWGATFAKTSAVYNPIVYGISHPKYRIVLKEKCPMC--VF--
---GNT-DEPKP-DAP-ASDTETTSEADS------KA-----------------------
------------------------------------------------------------
-----------
>    24== X65878   1 Drosophila pseudoobscura Dpse\Rh2 <>[Genetics132(1),193-204'92
-------------------MERSL-------------------------LPEPPLAMALL
GPRFE-----------------------------AQTGG------NRSVLDNVLPDMAPL
VNPHWSRFA-----PMDPTMSKILGLFTLVILIISCCGNGVVVYIFGGTKSLRTPANLLV
LNLAFSDFCMMASQ-SPVMIINFYY-ETWV--LGPLWCDIYAACGSLFGCVSIWSMCMIA
FDRYNVIVKGINGT-PMTIKTSIMKIAFIWMMAVFW-TIMPLIG-WS-----SYVPEGNL
TACSIDYMTRQ--WNPRSYLITYSLFVYYTPLFMICYSYWFIIATVAAHEKAMRDQAKKM
NVKS--------------------------------------------------------
------------------------------------------------------------
-------------LRS--------SEDCDKSAENKLAKVALTTISLWFMAWTPYLIICYF
GLF---KI-D-GLTPLTTIWGATFAKTSAVYNPIVYGISHPNDRLVLKEKCPMC--VC--
---GTT-DEPKP-DAP-PSDTETTSEAES------KD-----------------------
------------------------------------------------------------
-----------
>    25== U26026   1 Apis mellifera long-wavelength rhodopsin <>[]
-------------------------------------------------------MIAVS
GPSYE-----------------------------AFSYGGQARFNNQTVVDKVPPDMLHL
IDANWYQYP-----PLNPMWHGILGFVIGMLGFVSAMGNGMVVYIFLSTKSLRTPSNLFV
INLAISNFLMMFCM-SPPMVINCYY-ETWV--LGPLFCQIYAMLGSLFGCGSIWTMTMIA
FDRYNVIVKGLSGK-PLSINGALIRIIAIWLFSLGW-TIAPMFG-WN-----RYVPEGNM
TACGTDYFNRG--LLSASYLVCYGIWVYFVPLFLIIYSYWFIIQAVAAHEKNMREQAKKM
NVAS--------------------------------------------------------
------------------------------------------------------------
-------------LRS--------SENQNTSAECKLAKVALMTISLWFMAWTPYLVINFS
GIF---NL-V-KISPLFTIWGSLFAKANAVYNPIVYGISHPKYRAALFAKFPSL--AC--
----AA-EPSSD-AVS-TTSG-TTTVTDN------EKSNA--------------------
------------------------------------------------------------
-----------
>    26== L03781   1 Limulus polyphemus opsin <>[PNAS90,6150-6154'93]
-------------------MANQL------------------------------------
--SYS-----------------------------SLGWPYQP---NASVVDTMPKEMLYM
IHEHWYAFP-----PMNPLWYSILGVAMIILGIICVLGNGMVIYLMMTTKSLRTPTNLLV
VNLAFSDFCMMAFM-MPTMTSNCFA-ETWI--LGPFMCEVYGMAGSLFGCASIWSMVMIT
LDRYNVIVRGMAAA-PLTHKKATLLLLFVWIWSGGW-TILPFFG-WS-----RYVPEGNL
TSCTVDYLTKD--WSSASYVVIYGLAVYFLPLITMIYCYFFIVHAVAEHEKQLREQAKKM
NVAS--------------------------------------------------------
------------------------------------------------------------
-------------LRA-------NADQQKQSAECRLAKVAMMTVGLWFMAWTPYLIISWA
GVF---SSGT-RLTPLATIWGSVFAKANSCYNPIVYGISHPRYKAALYQRFPSL--AC--
---GSG-ESGSD-VKS-EASA-TTTMEEK------PKIPEA-------------------
------------------------------------------------------------
-----------
>    27== X07797   1 Octopus dofleini rhodopsin <>[FEBS232(1),69-72'88]
-------------------MVEST---------------------------TLVNQTWWY
NPTV-------------------------------------------------------D
IHPHWAKFD-----PIPDAVYYSVGIFIGVVGIIGILGNGVVIYLFSKTKSLQTPANMFI
INLAMSDLSFSAINGFPLKTISAFM-KKWI--FGKVACQLYGLLGGIFGFMSINTMAMIS
IDRYNVIGRPMAASKKMSHRRAFLMIIFVWMWSIVW-SVGPVFN-WG-----AYVPEGIL
TSCSFDYLSTD--PSTRSFILCMYFCGFMLPIIIIAFCYFNIVMSVSNHEKEMAAMAKRL
NAKE--------------------------------------------------------
------------------------------------------------------------
-------------LRK---------AQAGASAEMKLAKISMVIITQFMLSWSPYAIIALL
AQF---GPAE-WVTPYAAELPVLFAKASAIHNPIVYSVSHPKFREAIQTTFPWLLTCCQF
D------EKECE-DAN-DAEE-EVVASER----GGESRDAAQMKEMMAMMQKMQAQQAAY
QP---PPPPQGYPPQGYPPQGAYPPPQGYPPQGYPPQGYPPQGYPPQGAPPQVEAPQGAP
PQGVDNQAYQA
>    28== X70498   1 Todarodes pacificus rhodopsin <retina>[FEBS317(1-2),5-11'93]
-------------------MGRDL----------------------------RDNETWWY
NPSI-------------------------------------------------------V
VHPHWREFD-----QVPDAVYYSLGIFIGICGIIGCGGNGIVIYLFTKTKSLQTPANMFI
INLAFSDFTFSLVNGFPLMTISCFL-KKWI--FGFAACKVYGFIGGIFGFMSIMTMAMIS
IDRYNVIGRPMAASKKMSHRRAFIMIIFVWLWSVLW-AIGPIFG-WG-----AYTLEGVL
CNCSFDYISRD--STTRSNILCMFILGFFGPILIIFFCYFNIVMSVSNHEKEMAAMAKRL
NAKE--------------------------------------------------------
------------------------------------------------------------
-------------LRK---------AQAGANAEMRLAKISIVIVSQFLLSWSPYAVVALL
AQF---GPLE-WVTPYAAQLPVMFAKASAIHNPMIYSVSHPKFREAISQTFPWVLTCCQF
D------DKETE-DDK-DAET-EIPAGES--SDAAPSADAAQMKEMMAMMQKMQQQQAAY
PPQGYAPPPQGYPPQGYPPQGY--PPQGYPPQGYPP---PPQGAPPQGAPP------AAP
PQGVDNQAYQA
>    29== L21195   1 human serotonin 5-HT7 receptor protein <placenta and fetal bra
M------------------MDVNSSGR-----PDLYGHLRSFL------LPEVGRGLPDL
SPDG------------GADPVAGSWAPHLLS---EVTASPAP---T----WDAPPDNASG
CGEQI---------NYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI
VSLALADLSVAVAV-MPFVSVTDLIGGKWI--FGHFFCNVFIAMDVMCCTASIMTLCVIS
IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASI-TLPPLFG-WA-----QNVNDDKV
CLISQDF----------GYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPG---
----F-------PRVEPDSVIALNG-----------------------------------
-------------------IVKLQKE-------------------VEECAN---------
---------LSRLLKHE------RKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTA
RPFICGTSCS-CIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLL-----QCQY
RNINRK-------LSAAGMHE-ALKLAER------PERPEFVLQN-----ADYCRK---K
------------------------------------------------------------
-------GHDS
>    30== L15228   1 rat 5HT-7 serotonin receptor <>[JBC268,18200-18204'93]
------------------------------------------------------------
-------------------------MPHLLSGFLEVTASPAP---T----WDAPPDNVSG
CGEQI---------NYGRVEKVVIGSILTLITLLTIAGNCLVVISVSFVKKLRQPSNYLI
VSLALADLSVAVAV-MPFVSVTDLIGGKWI--FGHFFCNVFIAMDVMCCTASIMTLCVIS
IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASI-TLPPLFG-WA-----QNVNDDKV
CLISQDF----------GYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPG---
----F-------PRVQPESVISLNG-----------------------------------
-------------------VVKLQKE-------------------VEECAN---------
---------LSRLLKHE------RKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTA
RPFICGTSCS-CIPLWVERTCLWLGYANSLINPFIYAFFNRDLRPTSRSLL-----QCQY
RNINRK-------LSAAGMHE-ALKLAER------PERSEFVLQN-----SDHCGK---K
------------------------------------------------------------
-------GHDT
>    31=p A47425 serotonin receptor 5HT-7 - rat
------------------------------------------------------------
-------------------------MPHLLSGFLEVTASPAP---T----WDAPPDNVSG
CGEQI---------NYGRVEKVVIGSILTLITLLTIAGNCLVVISVSFVKKLRQPSNYLI
VSLALADLSVAVAV-MPFVSVTDLIGGKWI--FGHFFCNVFIAMDVMCCTASIMTLCVIS
IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASI-TLPPLFG-WA-----QNVNDDKV
CLISQDF----------GYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPG---
----F-------PRVQPESVISLNG-----------------------------------
-------------------VVKLQKE-------------------VEECAN---------
---------LSRLLKHE------RKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTA
RPFICGTSCS-CIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLL-----QCQY
RNINRK-------LSAAGMHE-ALKLAER------PERSEFVLQN-----SDHCGK---K
------------------------------------------------------------
-------GHDT
>    32== M83181   1 human serotonin receptor <>[JBC267(11),7553-7562'92]
-------------------MDVLSPG----------------------------------
--QG-----------------------------NNTTSPPAPFE----------------
TGGNTTGIS-----DVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLI
GSLAVTDLMVSVLV-LPMAALYQVL-NKWT--LGQVTCDLFIALDVLCCTSSILHLCAIA
LDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLI-SIPPMLG-WRTP---EDRSDPDA
CTISKDH----------GYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKT
GADTRHGASPAPQPKK-----SVNGE--SGSRNWRLGVESKAGGALC-------------
---------------------------ANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPS
EAG--PTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALV
LPF---CESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKII-----KCKF
CRQ---------------------------------------------------------
------------------------------------------------------------
-----------
>    33=p A35181 serotonin receptor class 1A - rat
-------------------MDVFSFG----------------------------------
--QG-----------------------------NNTTASQEPFG----------------
TGGNVTSIS-----DVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLI
GSLAVTDLMVSVLV-LPMAALYQVL-NKWT--LGQVTCDLFIALDVLCCTSSILHLCAIA
LDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLI-SIPPMLG-WRTP---EDRSDPDA
CTISKDH----------GYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKK
GAGTSLGTSSAPPPKK-----SLNGQ--PGSGDWRRCAENRAVGTPC-------------
---------------------------TNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPS
ESG--SNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALV
LPF---CESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKII-----KCKF
CRR---------------------------------------------------------
------------------------------------------------------------
-----------
>    34== L06803   1 Lymnaea stagnalis serotonin receptor <>[PNAS90,11-15'93]
MA-NFTFGDLA--------LDVARMG---------------GLASTPSGLRSTGLTTPGL
SPTGLVTSDFNDSYGLTGQFINGSHSSRSR---DNASANDTS--------------ATNM
TDDRYWSLT-----VYSHEHLVLTSVILGLFVLCCIIGNCFVIAAVMLERSLHNVANYLI
LSLAVADLMVAVLV-MPLSVVSEIS-KVWF--LHSEVCDMWISVDVLCCTASILHLVAIA
MDRYWAVTS-IDYIRRRSARRILLMIMVVWIVALFI-SIPPLFG-WRDP--NNDPDKTGT
CIISQDK----------GYTIFSTVGAFYLPMLVMMIIYIRIWLVARSRIRKDKFQMTKA
RLKTEETTLVASPKTEYSVVSDCNGCNSPDSTTEKKKRRAPFKSYGCSPRPERKKNRAKK
LPENANGVNSNSSS--SERLKQIQIETAEAFANGCAEEASIAML-ERQCNNGKK------
-------------ISSNDTPYSRTREKLELKRERKAARTLAIITGAFLICWLPFFIIALI
GPF---VDPE-GIPPFARSFVLWLGYFNSLLNPIIYTIFSPEFRSAFQKIL-----FGKY
RRGHR-------------------------------------------------------
------------------------------------------------------------
-----------
>    35=p A47174 serotonin receptor, 5HTlym receptor - great pond snail
MA-NFTFGDLA--------LDVARMG---------------GLASTPSGLRSTGLTTPGL
SPTGLVTSDFNDSYGLTGQFINGSHSSRSR---DNASANDTS--------------ATNM
TDDRYWSLT-----VYSHEHLVLTSVILGLFVLCCIIGNCFVIAAVMLERSLHNVANYLI
LSLAVADLMVAVLV-MPLSVVSEIS-KVWF--LHSEVCDMWISVDVLCCTASILHLVAIA
MDRYWAVTS-IDYIRRRSARRILLMIMVVWIVALFI-SIPPLFG-WRDP--NNDPDKTGT
CIISQDK----------GYTIFSTVGAFYLPMLVMMIIYIRIWLVARSRIRKDKFQMTKA
RLKTEETTLVASPKTEYSVVSDCNGCNSPDSTTEKKKRRAPFKSYGCSPRPERKKNRAKK
LPENANGVNSNSSS--SERLKQIQIETAEAFANGCAEEASIAML-ERQCNNGKK------
-------------ISSNDTPYSRTREKLELKRERKAARTLAIITGAFLICWLPFFIIALI
GPF---VDPE-GIPPFARSFVLWLGYFNSLLNPIIYTIFSPEFRSAFQKIL-----FGKY
RRGHR-------------------------------------------------------
------------------------------------------------------------
-----------
>    36== X95604   1 Bombyx mori serotonin receptor <antennae>[InsectBiochem.Mol.Bi
-------------------MEGAE-GQEELDWEALYLRLPL-------------------
---------------------------------QNCSWNSTG--------WEPNWNVTVV
PNTTWWQASAPFDTPAALVRAAAKAVVLGLLILATVVGNVFVIAAILLERHLRSAANNLI
LSLAVADLLVACLV-MPLGAVYEVV-QRWT--LGPELCDMWTSGDVLCCTASILHLVAIA
LDRYWAVTN-IDYIHASTAKRVGMMIACVWTVSFFV-CIAQLLG-WKDPDWNQRVSEDLR
CVVSQDV----------GYQIFATASSFYVPVLIILILYWRIYQTARKRIRRRRGATARG
GVGP--------PPVPAGGALVAGGG---------------------S------------
-----GGIAAAVVAVIGRPLPTISETTTTGFTNVSSNNTSPE---KQSCANGLEADPPTT
GYGAVAAAYYPSLVRRK------PKEAADSKRERKAAKTLAIITGAFVACWLPFFVLAIL
VPT---CDCE--VSPVLTSLSLWLGYFNSTLNPVIYTVFSPEFRHAFQRLL-----CGRR
VRRRRA-----------------------------PQ-----------------------
------------------------------------------------------------
-----------
